TY - JOUR
T1 - Nonlinear active stress – Principal strain relation during pulsation of human iPS cell derived cardiomyocyte sheet
AU - Kurita, Hiroko
AU - Todo, Mitsugu
N1 - Funding Information:
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mitsugu Todo reports financial support was provided by Japan Society for the Promotion of Science .
Funding Information:
This work was supported by JSPS KAKENHI Grant Number 18H01338 .
Funding Information:
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mitsugu Todo reports financial support was provided by Japan Society for the Promotion of Science.This work was supported by JSPS KAKENHI Grant Number 18H01338.
Publisher Copyright:
© 2021
PY - 2022/2
Y1 - 2022/2
N2 - Recently, a technique for differentiating human iPS cells into cardiomyocytes has been established and therefore, human iPS cell derived cardiomyocytes (hiPS-CM) can be utilized for the biomechanical study of myocardial tissues. In the present study, a sheet structure of hiPS-CM was fabricated using cell sheet technology and the pulsation behavior was measured using a high speed imaging system. The minimum principal strain was then evaluated using the digital correlation method and the active stress was calculated on the basis of the theoretical model proposed by Guccione et al. It was found that the active stress-strain behavior clearly exhibited a nonlinear viscoelastic response characterized by a hysteresis loop. This nonlinear response was also found to be effectively predicted by the constitutive equation derived from the viscoelastic Maxwell model. A microscopic mechanism involved in the hysteresis loop was also proposed on the basis of the sarcomere structure and mechanical behavior.
AB - Recently, a technique for differentiating human iPS cells into cardiomyocytes has been established and therefore, human iPS cell derived cardiomyocytes (hiPS-CM) can be utilized for the biomechanical study of myocardial tissues. In the present study, a sheet structure of hiPS-CM was fabricated using cell sheet technology and the pulsation behavior was measured using a high speed imaging system. The minimum principal strain was then evaluated using the digital correlation method and the active stress was calculated on the basis of the theoretical model proposed by Guccione et al. It was found that the active stress-strain behavior clearly exhibited a nonlinear viscoelastic response characterized by a hysteresis loop. This nonlinear response was also found to be effectively predicted by the constitutive equation derived from the viscoelastic Maxwell model. A microscopic mechanism involved in the hysteresis loop was also proposed on the basis of the sarcomere structure and mechanical behavior.
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U2 - 10.1016/j.mechmat.2021.104199
DO - 10.1016/j.mechmat.2021.104199
M3 - Article
AN - SCOPUS:85121697203
VL - 165
JO - Mechanics of Materials
JF - Mechanics of Materials
SN - 0167-6636
M1 - 104199
ER -