Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship

Takao Shimayoshi, Mitsuharu Mishima, Akira Amano, Tetsuya Matsuda

Research output: Contribution to journalArticle

Abstract

As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.

Original languageEnglish
Pages (from-to)6778-6781
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2014
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Linear Models
Blood Pressure
Nonlinear Dynamics
Cardiovascular System
Stroke Volume
Muscle Cells
Heart Ventricles
Cardiovascular system

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship. / Shimayoshi, Takao; Mishima, Mitsuharu; Amano, Akira; Matsuda, Tetsuya.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 2014, 2014, p. 6778-6781.

Research output: Contribution to journalArticle

@article{f6cec547e9a74927a871768727b77119,
title = "Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship",
abstract = "As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.",
author = "Takao Shimayoshi and Mitsuharu Mishima and Akira Amano and Tetsuya Matsuda",
year = "2014",
doi = "10.1109/EMBC.2014.6945184",
language = "English",
volume = "2014",
pages = "6778--6781",
journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
issn = "1557-170X",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

TY - JOUR

T1 - Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship

AU - Shimayoshi, Takao

AU - Mishima, Mitsuharu

AU - Amano, Akira

AU - Matsuda, Tetsuya

PY - 2014

Y1 - 2014

N2 - As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.

AB - As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.

UR - http://www.scopus.com/inward/record.url?scp=84944146851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944146851&partnerID=8YFLogxK

U2 - 10.1109/EMBC.2014.6945184

DO - 10.1109/EMBC.2014.6945184

M3 - Article

VL - 2014

SP - 6778

EP - 6781

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

SN - 1557-170X

ER -