Abstract
As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.
| Original language | English |
|---|---|
| Title of host publication | 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 6778-6781 |
| Number of pages | 4 |
| ISBN (Electronic) | 9781424479290 |
| DOIs | |
| Publication status | Published - Nov 2 2014 |
| Externally published | Yes |
| Event | 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States Duration: Aug 26 2014 → Aug 30 2014 |
Other
| Other | 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 |
|---|---|
| Country | United States |
| City | Chicago |
| Period | 8/26/14 → 8/30/14 |
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All Science Journal Classification (ASJC) codes
- Health Informatics
- Computer Science Applications
- Biomedical Engineering
- Medicine(all)
Cite this
Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship. / Shimayoshi, Takao; Mishima, Mitsuharu; Amano, Akira; Matsuda, Tetsuya.
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 6778-6781 6945184.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship
AU - Shimayoshi, Takao
AU - Mishima, Mitsuharu
AU - Amano, Akira
AU - Matsuda, Tetsuya
PY - 2014/11/2
Y1 - 2014/11/2
N2 - As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.
AB - As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.
UR - http://www.scopus.com/inward/record.url?scp=84929493917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929493917&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2014.6945184
DO - 10.1109/EMBC.2014.6945184
M3 - Conference contribution
SP - 6778
EP - 6781
BT - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PB - Institute of Electrical and Electronics Engineers Inc.
ER -