Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship

Takao Shimayoshi; Mitsuharu Mishima; Akira Amano; Tetsuya Matsuda

doi:10.1109/EMBC.2014.6945184

Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship

Takao Shimayoshi, Mitsuharu Mishima, Akira Amano, Tetsuya Matsuda

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.

Original language	English
Title of host publication	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	6778-6781
Number of pages	4
ISBN (Electronic)	9781424479290
DOIs	https://doi.org/10.1109/EMBC.2014.6945184
Publication status	Published - Nov 2 2014
Externally published	Yes
Event	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States Duration: Aug 26 2014 → Aug 30 2014

Publication series

Name	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Other

Other	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Country/Territory	United States
City	Chicago
Period	8/26/14 → 8/30/14

All Science Journal Classification (ASJC) codes

Health Informatics
Computer Science Applications
Biomedical Engineering
Medicine(all)

Access to Document

10.1109/EMBC.2014.6945184

Cite this

Shimayoshi, T., Mishima, M., Amano, A., & Matsuda, T. (2014). Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 6778-6781). [6945184] (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6945184

Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship. / Shimayoshi, Takao; Mishima, Mitsuharu; Amano, Akira et al.

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 6778-6781 6945184 (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Shimayoshi, T, Mishima, M, Amano, A & Matsuda, T 2014, Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship. in 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014., 6945184, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Institute of Electrical and Electronics Engineers Inc., pp. 6778-6781, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Chicago, United States, 8/26/14. https://doi.org/10.1109/EMBC.2014.6945184

Shimayoshi T, Mishima M, Amano A, Matsuda T. Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc. 2014. p. 6778-6781. 6945184. (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). doi: 10.1109/EMBC.2014.6945184

Shimayoshi, Takao ; Mishima, Mitsuharu ; Amano, Akira et al. / Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 6778-6781 (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

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abstract = "As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.",

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Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship

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