TY - GEN
T1 - Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship
AU - Shimayoshi, Takao
AU - Mishima, Mitsuharu
AU - Amano, Akira
AU - Matsuda, Tetsuya
PY - 2014/11/2
Y1 - 2014/11/2
N2 - As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.
AB - As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.
UR - http://www.scopus.com/inward/record.url?scp=84929493917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929493917&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2014.6945184
DO - 10.1109/EMBC.2014.6945184
M3 - Conference contribution
C2 - 25571552
AN - SCOPUS:84929493917
T3 - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
SP - 6778
EP - 6781
BT - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Y2 - 26 August 2014 through 30 August 2014
ER -