Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship

Takao Shimayoshi, Mitsuharu Mishima, Akira Amano, Tetsuya Matsuda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.

Original languageEnglish
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages6778-6781
Number of pages4
ISBN (Electronic)9781424479290
DOIs
Publication statusPublished - Nov 2 2014
Externally publishedYes
Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
Duration: Aug 26 2014Aug 30 2014

Publication series

Name2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Other

Other2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
CountryUnited States
CityChicago
Period8/26/148/30/14

All Science Journal Classification (ASJC) codes

  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering
  • Medicine(all)

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