Nonmyeloablative allogeneic bone marrow transplantation for treatment of myelodysplastic syndrome complicated by recent intracerebral hemorrhage

Korenori Ohtsubo, Ken Takase, Koji Nagafuji, Hideho Henzan, Tetsuya Tanimoto, Takahiro Fukuda, Toshihiro Miyamoto, Shoichi Inaba, Mine Harada

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with intracerebral hemorrhage is considered ineligible for hematopoietic stem cell transplantation (HSCT). We report a 49-year-old woman with myelodysplastic syndrome (MDS) complicated by refractoriness to platelet transfusion and intracerebral hemorrhage, who underwent allogeneic bone marrow transplantation from an HLA-identical unrelated male donor. Nine days before the scheduled transplantation, she developed dysarthria and right hemiparesis; computed tomography (CT) of the brain disclosed an acute hematoma in the left parietal lobe exceeding 3 cm in diameter. She underwent conditioning with reduced-intensity, including fludarabine (30 mg/m2/day on days -8 to -3), busulfan (4 mg/kg/day on days -6 and -5), and total body irradiation (4 Gy on day -2). Two weeks after transplantation, dysarthria and right hemiparesis began to resolve, and CT showed spontaneous resolution of the hematoma. Simultaneously, engraftment was confirmed. Thus, recent stroke may be not an absolute contraindication for HSCT.

Original languageEnglish
Pages (from-to)400-404
Number of pages5
JournalAmerican Journal of Hematology
Volume77
Issue number4
DOIs
Publication statusPublished - Dec 2004

All Science Journal Classification (ASJC) codes

  • Hematology

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