Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia

Eriko Nagasawa; Yasunobu Abe; Takamitsu Matsushima; Ilseung Choi; Yoshimichi Tachikawa; Rie Ohtsuka; Hideki Ishikura; Junji Nishimura; Shoichi Inaba; Hajime Nawata; Koichiro Muta

Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia

Eriko Nagasawa, Yasunobu Abe, Takamitsu Matsushima, Ilseung Choi, Yoshimichi Tachikawa, Rie Ohtsuka, Hideki Ishikura, Junji Nishimura, Shoichi Inaba, Hajime Nawata, Koichiro Muta

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We describe a 70-year-old woman with acute myelogenous leukemia with t(8;21) in the first relapse who underwent nonmyeloablative transplantation with conditioning of fludarabine and low-dose total body irradiation (2Gy). Myelosuppression was very mild, and the patient developed transient grade I renal and hepatic toxicities. Complete chimerism was achieved on day 120. The level of the AML1/MTG8 fusion gene in bone marrow decreased to an undetectable level on day 56 and the patient is alive and in complete remission with a follow-up at day 450. This transplant regimen might be well tolerated even by the elderly patients and bring a durable remission.

Original language	English
Pages (from-to)	167-169
Number of pages	3
Journal	[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume	45
Issue number	2
Publication status	Published - Feb 2004

All Science Journal Classification (ASJC) codes

Medicine(all)

Cite this

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title = "Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia",

abstract = "We describe a 70-year-old woman with acute myelogenous leukemia with t(8;21) in the first relapse who underwent nonmyeloablative transplantation with conditioning of fludarabine and low-dose total body irradiation (2Gy). Myelosuppression was very mild, and the patient developed transient grade I renal and hepatic toxicities. Complete chimerism was achieved on day 120. The level of the AML1/MTG8 fusion gene in bone marrow decreased to an undetectable level on day 56 and the patient is alive and in complete remission with a follow-up at day 450. This transplant regimen might be well tolerated even by the elderly patients and bring a durable remission.",

author = "Eriko Nagasawa and Yasunobu Abe and Takamitsu Matsushima and Ilseung Choi and Yoshimichi Tachikawa and Rie Ohtsuka and Hideki Ishikura and Junji Nishimura and Shoichi Inaba and Hajime Nawata and Koichiro Muta",

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T1 - Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia

AU - Nagasawa, Eriko

AU - Abe, Yasunobu

AU - Matsushima, Takamitsu

AU - Choi, Ilseung

AU - Tachikawa, Yoshimichi

AU - Ohtsuka, Rie

AU - Ishikura, Hideki

AU - Nishimura, Junji

AU - Inaba, Shoichi

AU - Nawata, Hajime

AU - Muta, Koichiro

PY - 2004/2

Y1 - 2004/2

N2 - We describe a 70-year-old woman with acute myelogenous leukemia with t(8;21) in the first relapse who underwent nonmyeloablative transplantation with conditioning of fludarabine and low-dose total body irradiation (2Gy). Myelosuppression was very mild, and the patient developed transient grade I renal and hepatic toxicities. Complete chimerism was achieved on day 120. The level of the AML1/MTG8 fusion gene in bone marrow decreased to an undetectable level on day 56 and the patient is alive and in complete remission with a follow-up at day 450. This transplant regimen might be well tolerated even by the elderly patients and bring a durable remission.

AB - We describe a 70-year-old woman with acute myelogenous leukemia with t(8;21) in the first relapse who underwent nonmyeloablative transplantation with conditioning of fludarabine and low-dose total body irradiation (2Gy). Myelosuppression was very mild, and the patient developed transient grade I renal and hepatic toxicities. Complete chimerism was achieved on day 120. The level of the AML1/MTG8 fusion gene in bone marrow decreased to an undetectable level on day 56 and the patient is alive and in complete remission with a follow-up at day 450. This transplant regimen might be well tolerated even by the elderly patients and bring a durable remission.

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Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia

Abstract

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