Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia

Eriko Nagasawa, Yasunobu Abe, Takamitsu Matsushima, Ilseung Choi, Yoshimichi Tachikawa, Rie Ohtsuka, Hideki Ishikura, Junji Nishimura, Shoichi Inaba, Hajime Nawata, Koichiro Muta

Research output: Contribution to journalArticle

Abstract

We describe a 70-year-old woman with acute myelogenous leukemia with t(8;21) in the first relapse who underwent nonmyeloablative transplantation with conditioning of fludarabine and low-dose total body irradiation (2Gy). Myelosuppression was very mild, and the patient developed transient grade I renal and hepatic toxicities. Complete chimerism was achieved on day 120. The level of the AML1/MTG8 fusion gene in bone marrow decreased to an undetectable level on day 56 and the patient is alive and in complete remission with a follow-up at day 450. This transplant regimen might be well tolerated even by the elderly patients and bring a durable remission.

Original languageEnglish
Pages (from-to)167-169
Number of pages3
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume45
Issue number2
Publication statusPublished - Feb 2004

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Nagasawa, E., Abe, Y., Matsushima, T., Choi, I., Tachikawa, Y., Ohtsuka, R., Ishikura, H., Nishimura, J., Inaba, S., Nawata, H., & Muta, K. (2004). Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia. [Rinshō ketsueki] The Japanese journal of clinical hematology, 45(2), 167-169.