Nonmyeloablative stem cell transplantation with low-dose total body irradiation (200 cGy) for a 55-year-old woman with acute lymphoblastic leukemia

Y. Abe, K. Hara, I. Choi, M. Shiratsuchi, T. Matsushima, R. Minami, T. Kihara, J. Nishimura, S. Inaba, H. Nawata, K. Muta

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Abstract

We describe a 55-year-old woman with acute lymphoblastic leukemia (ALL) in the first remission who underwent nonmyeloablative stem cell transplantation with conditioning consisting of low-dose total body irradiation and postgrafting cyclosporine and mycophenolate mofetil. Myelosuppression was mild, but on day 28 her bone marrow showed 8.8% lymphoblasts. We withdrew the cyclosporine, but the patient developed grade 2 acute GVHD and eosinophilia. The proportion of bone marrow lymphoblasts decreased transiently to 1.0% on day 40, but later increased again and the patient died on day 85. Application of this approach to patients with ALL needs to be examined on a large scale.

Original languageEnglish
Pages (from-to)1277-1280
Number of pages4
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume41
Issue number12
Publication statusPublished - Dec 2000

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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