TY - JOUR
T1 - Notch-mediated lateral inhibition regulates proneural wave propagation when combined with EGF-mediated reaction diffusion
AU - Sato, Makoto
AU - Yasugi, Tetsuo
AU - Minami, Yoshiaki
AU - Miura, Takashi
AU - Nagayama, Masaharu
N1 - Funding Information:
We thank Rie Takayama and members of the laboratory of M.S. for supporting fly work; S. Ei for helpful discussion; R. Kageyama, S. Hayashi, T. Hayashi T. Tabata, D. Umetsu, and K. Uriu for critical comments; and S. Bray, J. Skeath, T. Tabata, Bloomington Drosophila Stock Center, Drosophila Genetic Resource Center, Kyoto, and Developmental Studies Hybridoma Bank for flies and antibodies. This work was supported by Precursory Research for Embryonic Science and Technology from Japan Science and Technology Agency (JST), a Grant-in-Aid for Scientific Research on Innovative Areas and a Grant-in-Aid for Scientific Research (B) from Ministry of Education, Culture, Sports, Science, and Technology, the Sekisui Chemical Grant Program, the Asahi Glass Foundation (M.S.), Core Research for Evolutional Science and Technology from JST, and Cooperative Research of "Network Joint Research Center forMaterials and Devices" (M.S., T.M., and M.N.).
PY - 2016/8/30
Y1 - 2016/8/30
N2 - Notch-mediated lateral inhibition regulates binary cell fate choice, resulting in salt and pepper patterns during various developmental processes. However, how Notch signaling behaves in combination with other signaling systems remains elusive. The wave of differentiation in the Drosophila visual center or "proneural wave" accompanies Notch activity that is propagated without the formation of a salt and pepper pattern, implying that Notch does not form a feedback loop of lateral inhibition during this process. However, mathematical modeling and genetic analysis clearly showed that Notch-mediated lateral inhibition is implemented within the proneural wave. Because partial reduction in EGF signaling causes the formation of the salt and pepper pattern, it is most likely that EGF diffusion cancels salt and pepper pattern formation in silico and in vivo. Moreover, the combination of Notch-mediated lateral inhibition and EGF-mediated reaction diffusion enables a function of Notch signaling that regulates propagation of the wave of differentiation.
AB - Notch-mediated lateral inhibition regulates binary cell fate choice, resulting in salt and pepper patterns during various developmental processes. However, how Notch signaling behaves in combination with other signaling systems remains elusive. The wave of differentiation in the Drosophila visual center or "proneural wave" accompanies Notch activity that is propagated without the formation of a salt and pepper pattern, implying that Notch does not form a feedback loop of lateral inhibition during this process. However, mathematical modeling and genetic analysis clearly showed that Notch-mediated lateral inhibition is implemented within the proneural wave. Because partial reduction in EGF signaling causes the formation of the salt and pepper pattern, it is most likely that EGF diffusion cancels salt and pepper pattern formation in silico and in vivo. Moreover, the combination of Notch-mediated lateral inhibition and EGF-mediated reaction diffusion enables a function of Notch signaling that regulates propagation of the wave of differentiation.
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U2 - 10.1073/pnas.1602739113
DO - 10.1073/pnas.1602739113
M3 - Article
C2 - 27535937
AN - SCOPUS:84984697600
SN - 0027-8424
VL - 113
SP - E5153-E5162
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 35
ER -