Notch-mediated lateral inhibition regulates proneural wave propagation when combined with EGF-mediated reaction diffusion

Makoto Sato, Tetsuo Yasugi, Yoshiaki Minami, Takashi Miura, Masaharu Nagayama

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Notch-mediated lateral inhibition regulates binary cell fate choice, resulting in salt and pepper patterns during various developmental processes. However, how Notch signaling behaves in combination with other signaling systems remains elusive. The wave of differentiation in the Drosophila visual center or "proneural wave" accompanies Notch activity that is propagated without the formation of a salt and pepper pattern, implying that Notch does not form a feedback loop of lateral inhibition during this process. However, mathematical modeling and genetic analysis clearly showed that Notch-mediated lateral inhibition is implemented within the proneural wave. Because partial reduction in EGF signaling causes the formation of the salt and pepper pattern, it is most likely that EGF diffusion cancels salt and pepper pattern formation in silico and in vivo. Moreover, the combination of Notch-mediated lateral inhibition and EGF-mediated reaction diffusion enables a function of Notch signaling that regulates propagation of the wave of differentiation.

Original languageEnglish
Pages (from-to)E5153-E5162
JournalProceedings of the National Academy of Sciences of the United States of America
Volume113
Issue number35
DOIs
Publication statusPublished - Aug 30 2016

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All Science Journal Classification (ASJC) codes

  • General

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