Novel acylated triterpene glycosides from Muraltia heisteria

Mohamed Elbandy, Tomofumi Miyamoto, Bruno Chauffert, Clément Delaude, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Four new acylated triterpene glycosides (1-4) have been isolated as two inseparable mixtures of the trans- and cis-3,4,5-trimethoxycinnamoyl derivatives (1,2 and 3,4) from the roots of Muraltia heisteria. The structures of these compounds were elucidated by various 1D and 2D NMR techniques, including 1H and 13C, COSY, NOESY, HSQC, TOCSY, and HMBC experiments and FABMS: Compounds 3 and 4 were shown to be cytotoxic in a human colon cancer cell line but did not show any ability to potentiate in vitro cisplatin cytotoxicity.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalJournal of Natural Products
Volume65
Issue number2
DOIs
Publication statusPublished - Mar 6 2002

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Triterpenes
cisplatin
Cytotoxicity
Glycosides
colorectal neoplasms
triterpenoids
Colonic Neoplasms
Cisplatin
glycosides
cytotoxicity
Cells
cell lines
Nuclear magnetic resonance
Derivatives
Cell Line
Experiments
methodology
neoplasm cells
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Elbandy, M., Miyamoto, T., Chauffert, B., Delaude, C., & Lacaille-Dubois, M. A. (2002). Novel acylated triterpene glycosides from Muraltia heisteria. Journal of Natural Products, 65(2), 193-197. https://doi.org/10.1021/np010381+

Novel acylated triterpene glycosides from Muraltia heisteria. / Elbandy, Mohamed; Miyamoto, Tomofumi; Chauffert, Bruno; Delaude, Clément; Lacaille-Dubois, Marie Aleth.

In: Journal of Natural Products, Vol. 65, No. 2, 06.03.2002, p. 193-197.

Research output: Contribution to journalArticle

Elbandy, M, Miyamoto, T, Chauffert, B, Delaude, C & Lacaille-Dubois, MA 2002, 'Novel acylated triterpene glycosides from Muraltia heisteria', Journal of Natural Products, vol. 65, no. 2, pp. 193-197. https://doi.org/10.1021/np010381+
Elbandy, Mohamed ; Miyamoto, Tomofumi ; Chauffert, Bruno ; Delaude, Clément ; Lacaille-Dubois, Marie Aleth. / Novel acylated triterpene glycosides from Muraltia heisteria. In: Journal of Natural Products. 2002 ; Vol. 65, No. 2. pp. 193-197.
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