Novel applications of dds on infectious diseases and future prospect “drug delivery system responding to cellular signals in infected cells”

Yoko Shoji, Hideki Nakashima, Kouta Kodama, Yoshiki Katayama

Research output: Contribution to journalArticle

Abstract

In this study, we designed a peptide which is specifically cleaved by HIV protease as a gene/drug carrier. This is based on a new concept of a drug delivery system (DDS) responding to intracellular signals. We observed that this peptide was cleaved by recombinant HIV protease and HIV infected cells. In this system, the gene/drug can be released only in HIV infected cells. Since drugs could be activated only in infected cells, this system has a potential to raise the efficacy of drugs and reduce their side effects. As a biological signal, nitric oxide (NO) has aroused much attention. NO is a promising biological signal as well as a HIV protease in the new concept of DDS. However, it is extremely difficult to measure directly because of extreme short half-life time. We will introduce our system to measure NO directly by an electrode method.

Original languageEnglish
Pages (from-to)505-515
Number of pages11
JournalDrug Delivery System
Volume21
Issue number5
DOIs
Publication statusPublished - Jan 1 2006

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HIV Protease
Drug Delivery Systems
Communicable Diseases
Nitric Oxide
HIV
Pharmaceutical Preparations
Peptides
Drug Carriers
Genes
Half-Life
Electrodes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Novel applications of dds on infectious diseases and future prospect “drug delivery system responding to cellular signals in infected cells”. / Shoji, Yoko; Nakashima, Hideki; Kodama, Kouta; Katayama, Yoshiki.

In: Drug Delivery System, Vol. 21, No. 5, 01.01.2006, p. 505-515.

Research output: Contribution to journalArticle

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