Novel cage-type azaparacyclophane bearing chiral binding sites

Yukito Murakami, Teruhisa Ohno, Osamu Hayashida, Yoshio Hisaeda

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33 Citations (Scopus)

Abstract

The guest-binding behaviour of a novel cage-type azaparacyclophane, which has been prepared by the reaction of N,N′,N″,N‴-tetravalyl-1, 6,20,25-tetraaza[6.1.6.1]paracyclophane with N,N′,N″,N‴- tetrakis(5-carboxynicotinoyl)-2,11,20,29-tetraaza[3.3.3.3]paracyclophane, was examined in aqueous media and evaluated by a computer-aided molecular modelling study on the basis of molecular mechanics (MM2 and MMP2) and molecular dynamics (AMBER and CHARMM) conformational search.

Original languageEnglish
Pages (from-to)950-952
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number14
DOIs
Publication statusPublished - Dec 1 1991

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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