Novel class of DNA binding motifs based on bistetrahydrofuran and bisfuran skeleton with long alkyl chains

Shigeki Sasaki, Takayuki Shibata, Hidemine Torigoe, Yosinori Shibata, Minoru Maeda

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Small molecules with DNA-binding affinity within the minor groove have become of great interest. In this paper, new DNA binding molecules; diaminobistetrahydrofuran (bisTHF) and diamino-bisfuran are reported. The bisTHF ligand with RR configuration at the amino groups and C8 alkyl chains (RR8) stabilized GC-rich duplex. In contrast, bisfuran compounds stabilized AT-rich duplex. The binding affinity of RR8 with 12 mer duplex DNA was determined by isothermal titration calorimetry to be 3.3 × 108 M-1.

Original languageEnglish
Pages (from-to)551-558
Number of pages8
JournalNucleosides, Nucleotides and Nucleic Acids
Volume20
Issue number4-7
DOIs
Publication statusPublished - Jan 1 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Genetics

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