TY - JOUR
T1 - Novel class of DNA binding motifs based on bistetrahydrofuran and bisfuran skeleton with long alkyl chains
AU - Sasaki, Shigeki
AU - Shibata, Takayuki
AU - Torigoe, Hidemine
AU - Shibata, Yosinori
AU - Maeda, Minoru
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Small molecules with DNA-binding affinity within the minor groove have become of great interest. In this paper, new DNA binding molecules; diaminobistetrahydrofuran (bisTHF) and diamino-bisfuran are reported. The bisTHF ligand with RR configuration at the amino groups and C8 alkyl chains (RR8) stabilized GC-rich duplex. In contrast, bisfuran compounds stabilized AT-rich duplex. The binding affinity of RR8 with 12 mer duplex DNA was determined by isothermal titration calorimetry to be 3.3 × 108 M-1.
AB - Small molecules with DNA-binding affinity within the minor groove have become of great interest. In this paper, new DNA binding molecules; diaminobistetrahydrofuran (bisTHF) and diamino-bisfuran are reported. The bisTHF ligand with RR configuration at the amino groups and C8 alkyl chains (RR8) stabilized GC-rich duplex. In contrast, bisfuran compounds stabilized AT-rich duplex. The binding affinity of RR8 with 12 mer duplex DNA was determined by isothermal titration calorimetry to be 3.3 × 108 M-1.
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U2 - 10.1081/NCN-100002331
DO - 10.1081/NCN-100002331
M3 - Article
C2 - 11563072
AN - SCOPUS:0034850917
VL - 20
SP - 551
EP - 558
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
SN - 1525-7770
IS - 4-7
ER -