Small molecules with DNA-binding affinity within the minor groove have become of great interest. In this paper, new DNA binding molecules; diaminobistetrahydrofuran (bisTHF) and diamino-bisfuran are reported. The bisTHF ligand with RR configuration at the amino groups and C8 alkyl chains (RR8) stabilized GC-rich duplex. In contrast, bisfuran compounds stabilized AT-rich duplex. The binding affinity of RR8 with 12 mer duplex DNA was determined by isothermal titration calorimetry to be 3.3 × 108 M-1.
All Science Journal Classification (ASJC) codes
- Molecular Medicine