Novel DNA-binding ligands with sequence selectivity based on hydrophobic structure.

T. Shibata, H. Torigoe, Y. Shibata, M. Maeda, S. Sasaki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We have developed diamino-bistetrahydrofuran compounds (diamino-bisTHF) as new DNA binding molecules. Diamino-bisTHF (3:RR8) stabilized GC-rich duplex DNA with sequence specificity. DNA binding affinity increased as the alkyl chain was lengthened, indicating that the hydrophobic interaction is essential for DNA binding. It was also found that DNA binding affinity of the ligands depends on the stereochemistry of the amino group. In thermodynamic evaluation, diamino-bisTHF (3:RR8) showed a high affinity to the 12 bp duplex at a molar ratio of 1:1.

Original languageEnglish
Pages (from-to)251-252
Number of pages2
JournalNucleic acids symposium series
Issue number42
DOIs
Publication statusPublished - 1999

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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