Novel fabrication of nano-rod array structures on titanium and in vitro cell responses

Yongxing Liu, Weihui Chen, Yunzhi Yang, Joo L. Ong, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Nano-scale rod arrays of titania were fabricated on titanium surface by a glass phase topotaxy growth (GPT) method, which was featured by an interfacial reaction between sodium tetraborate coating and the preheated metallic titanium at elevated temperature. The samples were characterized by thin-film X-ray diffraction (XRD), scanning electron microscope (SEM), profilometer and contact angle measurement. Thin-film XRD analysis indicated that the nano-rod arrays were composed of pure rutile titania phase. SEM images showed that these rutile rods were 100-200 nm wide and 1-2 μm long. The nano-rod arrays had significantly higher average roughness (P < 0.05) and greater hydrophilicity (P < 0.05) compared to the control. Human embryonic palatal mesenchymal (HEPM) cells were grown to evaluate in vitro cell responses to the nano-rod array structures in terms of cell attachment and proliferation. An equivalent high attachment rate of 94% was observed after 4-h incubation, but a lower proliferation rate was observed on the nano-rod array after 12-day culture compared to the control (P < 0.05).

Original languageEnglish
Pages (from-to)2735-2741
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Volume19
Issue number7
DOIs
Publication statusPublished - Jul 1 2008

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Titanium
Fabrication
X-Ray Diffraction
Electron microscopes
Electrons
Scanning
Sodium borate
Thin films
Hydrophilicity
Angle measurement
Surface chemistry
Hydrophobic and Hydrophilic Interactions
X ray diffraction analysis
Contact angle
Glass
Surface roughness
Cell Proliferation
X ray diffraction
Coatings
Temperature

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Novel fabrication of nano-rod array structures on titanium and in vitro cell responses. / Liu, Yongxing; Chen, Weihui; Yang, Yunzhi; Ong, Joo L.; Tsuru, Kanji; Hayakawa, Satoshi; Osaka, Akiyoshi.

In: Journal of Materials Science: Materials in Medicine, Vol. 19, No. 7, 01.07.2008, p. 2735-2741.

Research output: Contribution to journalArticle

Liu, Yongxing ; Chen, Weihui ; Yang, Yunzhi ; Ong, Joo L. ; Tsuru, Kanji ; Hayakawa, Satoshi ; Osaka, Akiyoshi. / Novel fabrication of nano-rod array structures on titanium and in vitro cell responses. In: Journal of Materials Science: Materials in Medicine. 2008 ; Vol. 19, No. 7. pp. 2735-2741.
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