Novel laparoscopic narrow band imaging for real-time detection of bile leak during hepatectomy

proof of the concept in a porcine model

Michele Diana, Hameed Usmaan, Andras Legnèr, Liu Yu-Yin, Antonio D’Urso, Peter Halvax, Yoshihiro Nagao, Patrick Pessaux, Jacques Marescaux

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction: Bile leakage is a serious complication occurring in up to 10 % of hepatic resections. Intraoperative detection of bile leakage is challenging, and concomitant blood oozing can mask the presence of bile. Intraductal dye injection [methylene blue or indocyanine green (ICG)] is a validated technique to detect bile leakage. However, this method is time-consuming, particularly in the laparoscopic setting. A novel narrow band imaging (NBI) modality (SPECTRA-A; Karl Storz, Tuttlingen, Germany) allows easy discrimination of the presence of bile, which appears in clear orange, by image processing. The aim of this experimental study was to evaluate SPECTRA-A ability to detect bile leakage. Methods: Twelve laparoscopic partial hepatectomies were performed in seven pigs. The common bile duct was clipped distally and dissected, and a catheter was inserted and secured with a suture or a clip. Liver dissection was achieved with an ultrasonic cutting device. Dissection surfaces were checked by frequently switching on the SPECTRA filter to identify the presence of bile leakage. Intraductal ICG injection through the catheter was performed to confirm SPECTRA findings. Results: Three active bile leakages were obtained out of 12 hepatectomies and successfully detected intraoperatively by the SPECTRA. There was complete concordance between NBI and ICG fluorescence detection. No active leaks were found in the remaining cases with both techniques. The leaking area identified was sutured, and SPECTRA was used to assess the success of the repair. Conclusions: The SPECTRA laparoscopic image processing system allows for rapid detection of bile leaks following hepatectomy without any contrast injection.

Original languageEnglish
Pages (from-to)3128-3132
Number of pages5
JournalSurgical endoscopy
Volume30
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

Fingerprint

Narrow Band Imaging
Hepatectomy
Bile
Swine
Indocyanine Green
Injections
Dissection
Catheters
Methylene Blue
Liver
Common Bile Duct
Masks
Surgical Instruments
Ultrasonics
Sutures
Germany
Coloring Agents
Fluorescence

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Novel laparoscopic narrow band imaging for real-time detection of bile leak during hepatectomy : proof of the concept in a porcine model. / Diana, Michele; Usmaan, Hameed; Legnèr, Andras; Yu-Yin, Liu; D’Urso, Antonio; Halvax, Peter; Nagao, Yoshihiro; Pessaux, Patrick; Marescaux, Jacques.

In: Surgical endoscopy, Vol. 30, No. 7, 01.07.2016, p. 3128-3132.

Research output: Contribution to journalArticle

Diana, M, Usmaan, H, Legnèr, A, Yu-Yin, L, D’Urso, A, Halvax, P, Nagao, Y, Pessaux, P & Marescaux, J 2016, 'Novel laparoscopic narrow band imaging for real-time detection of bile leak during hepatectomy: proof of the concept in a porcine model', Surgical endoscopy, vol. 30, no. 7, pp. 3128-3132. https://doi.org/10.1007/s00464-015-4569-z
Diana, Michele ; Usmaan, Hameed ; Legnèr, Andras ; Yu-Yin, Liu ; D’Urso, Antonio ; Halvax, Peter ; Nagao, Yoshihiro ; Pessaux, Patrick ; Marescaux, Jacques. / Novel laparoscopic narrow band imaging for real-time detection of bile leak during hepatectomy : proof of the concept in a porcine model. In: Surgical endoscopy. 2016 ; Vol. 30, No. 7. pp. 3128-3132.
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abstract = "Introduction: Bile leakage is a serious complication occurring in up to 10 {\%} of hepatic resections. Intraoperative detection of bile leakage is challenging, and concomitant blood oozing can mask the presence of bile. Intraductal dye injection [methylene blue or indocyanine green (ICG)] is a validated technique to detect bile leakage. However, this method is time-consuming, particularly in the laparoscopic setting. A novel narrow band imaging (NBI) modality (SPECTRA-A; Karl Storz, Tuttlingen, Germany) allows easy discrimination of the presence of bile, which appears in clear orange, by image processing. The aim of this experimental study was to evaluate SPECTRA-A ability to detect bile leakage. Methods: Twelve laparoscopic partial hepatectomies were performed in seven pigs. The common bile duct was clipped distally and dissected, and a catheter was inserted and secured with a suture or a clip. Liver dissection was achieved with an ultrasonic cutting device. Dissection surfaces were checked by frequently switching on the SPECTRA filter to identify the presence of bile leakage. Intraductal ICG injection through the catheter was performed to confirm SPECTRA findings. Results: Three active bile leakages were obtained out of 12 hepatectomies and successfully detected intraoperatively by the SPECTRA. There was complete concordance between NBI and ICG fluorescence detection. No active leaks were found in the remaining cases with both techniques. The leaking area identified was sutured, and SPECTRA was used to assess the success of the repair. Conclusions: The SPECTRA laparoscopic image processing system allows for rapid detection of bile leaks following hepatectomy without any contrast injection.",
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T2 - proof of the concept in a porcine model

AU - Diana, Michele

AU - Usmaan, Hameed

AU - Legnèr, Andras

AU - Yu-Yin, Liu

AU - D’Urso, Antonio

AU - Halvax, Peter

AU - Nagao, Yoshihiro

AU - Pessaux, Patrick

AU - Marescaux, Jacques

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N2 - Introduction: Bile leakage is a serious complication occurring in up to 10 % of hepatic resections. Intraoperative detection of bile leakage is challenging, and concomitant blood oozing can mask the presence of bile. Intraductal dye injection [methylene blue or indocyanine green (ICG)] is a validated technique to detect bile leakage. However, this method is time-consuming, particularly in the laparoscopic setting. A novel narrow band imaging (NBI) modality (SPECTRA-A; Karl Storz, Tuttlingen, Germany) allows easy discrimination of the presence of bile, which appears in clear orange, by image processing. The aim of this experimental study was to evaluate SPECTRA-A ability to detect bile leakage. Methods: Twelve laparoscopic partial hepatectomies were performed in seven pigs. The common bile duct was clipped distally and dissected, and a catheter was inserted and secured with a suture or a clip. Liver dissection was achieved with an ultrasonic cutting device. Dissection surfaces were checked by frequently switching on the SPECTRA filter to identify the presence of bile leakage. Intraductal ICG injection through the catheter was performed to confirm SPECTRA findings. Results: Three active bile leakages were obtained out of 12 hepatectomies and successfully detected intraoperatively by the SPECTRA. There was complete concordance between NBI and ICG fluorescence detection. No active leaks were found in the remaining cases with both techniques. The leaking area identified was sutured, and SPECTRA was used to assess the success of the repair. Conclusions: The SPECTRA laparoscopic image processing system allows for rapid detection of bile leaks following hepatectomy without any contrast injection.

AB - Introduction: Bile leakage is a serious complication occurring in up to 10 % of hepatic resections. Intraoperative detection of bile leakage is challenging, and concomitant blood oozing can mask the presence of bile. Intraductal dye injection [methylene blue or indocyanine green (ICG)] is a validated technique to detect bile leakage. However, this method is time-consuming, particularly in the laparoscopic setting. A novel narrow band imaging (NBI) modality (SPECTRA-A; Karl Storz, Tuttlingen, Germany) allows easy discrimination of the presence of bile, which appears in clear orange, by image processing. The aim of this experimental study was to evaluate SPECTRA-A ability to detect bile leakage. Methods: Twelve laparoscopic partial hepatectomies were performed in seven pigs. The common bile duct was clipped distally and dissected, and a catheter was inserted and secured with a suture or a clip. Liver dissection was achieved with an ultrasonic cutting device. Dissection surfaces were checked by frequently switching on the SPECTRA filter to identify the presence of bile leakage. Intraductal ICG injection through the catheter was performed to confirm SPECTRA findings. Results: Three active bile leakages were obtained out of 12 hepatectomies and successfully detected intraoperatively by the SPECTRA. There was complete concordance between NBI and ICG fluorescence detection. No active leaks were found in the remaining cases with both techniques. The leaking area identified was sutured, and SPECTRA was used to assess the success of the repair. Conclusions: The SPECTRA laparoscopic image processing system allows for rapid detection of bile leaks following hepatectomy without any contrast injection.

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