Novel neuroglial and glioglial relationships mediated by L-serine metabolism

Shigeki Furuya, Masahiko Watanabe

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

L-Serine is a non-essential amino acid that can be synthesized in the body. It derives from an intermediate of the glycolytic pathway, 3-phosphoglycerate, and utilized for the syntheses of proteins, other amino acids, membrane lipids, heme, and nucleotides. Emerging evidence indicates that L-serine functions as a glia-derived trophic factor, which strongly promotes the survival and differentiation of cultured neurons. L-Serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase (3PGDH) and small neutral amino acid transporter ASCT1 have been revealed to be expressed preferentially in the radial glia-astrocyte lineage and olfactory ensheathing glia of both adult and developing rodent brains. In contrast, these biosynthetic and transporter molecules for L-serine are faint or undetectable in neurons and phagocytic cells. In this review, we summarize recent progress to propose that L-serine synthesis in these glial cells and its supply to nearby neurons and other glia constitute a novel metabolic unit in the brain. Based on these neuroglial and glioglial relationships, glucose in neurons and phogocytes can be strategically used for energy production, while a variety of L-serine-derived biomolecules required for their proliferaton, survival, differentiation, and function are synthesized in and supplied from the radial glia-astrocyte lineage and olfactory ensheathing glia. A transient capillary expression of ASCT1 in fetal and neonatal brains further suggests that, in addition to the glia-borne L-serine, an active transport of blood-borne L-serine would play an essential role in neural development.

Original languageEnglish
Pages (from-to)109-121
Number of pages13
JournalArchives of Histology and Cytology
Volume66
Issue number2
DOIs
Publication statusPublished - May 1 2003
Externally publishedYes

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Neuroglia
Serine
Neurons
Astrocytes
Phosphoglycerate Dehydrogenase
Brain
Neutral Amino Acid Transport Systems
Amino Acids
Active Biological Transport
Phagocytes
Membrane Lipids
Heme
Rodentia
Nucleotides
Glucose
Enzymes
Proteins

All Science Journal Classification (ASJC) codes

  • Histology

Cite this

Novel neuroglial and glioglial relationships mediated by L-serine metabolism. / Furuya, Shigeki; Watanabe, Masahiko.

In: Archives of Histology and Cytology, Vol. 66, No. 2, 01.05.2003, p. 109-121.

Research output: Contribution to journalReview article

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