Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese

Tetsuya Saito, Mari Egashira, Kazuma Kiyotani, Masaki Fujieda, Hiroshi Yamazaki, Chikako Kiyohara, Hideo Kunitoh, Tetsuya Kamataki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile448Asn, Arg464Cys, and Arg477Trp and Pro492Arg, respectively) were as follows: SNP, 030212Saito001; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTC A ACCC ATCT-/TG AGTTCCT ACCT-3'. SNP, 030212Saito002; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTG AG A AGGTG AT / AT ATCTTTGGC AT-3'. SNP, 030212Saito003; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GAGACCGTTGCCC/TGCTGGGAGGTCT-3'. SNP, 030212Saito004; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' - ATCCTGCTGC A A C /TGGGTGG A ATTC A-3'. SNP, 030212Saito005; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' -TGG ACATG ACCCC /GC ATCT ATGGGCT-3'.

Original languageEnglish
Pages (from-to)218-221
Number of pages4
JournalDrug Metabolism and Pharmacokinetics
Volume18
Issue number3
DOIs
Publication statusPublished - Feb 1 2003

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Cytochrome P-450 CYP1A1
Single Nucleotide Polymorphism
Names
Genes
Nonsense Codon
Exons

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

Saito, T., Egashira, M., Kiyotani, K., Fujieda, M., Yamazaki, H., Kiyohara, C., ... Kamataki, T. (2003). Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese. Drug Metabolism and Pharmacokinetics, 18(3), 218-221. https://doi.org/10.2133/dmpk.18.218

Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese. / Saito, Tetsuya; Egashira, Mari; Kiyotani, Kazuma; Fujieda, Masaki; Yamazaki, Hiroshi; Kiyohara, Chikako; Kunitoh, Hideo; Kamataki, Tetsuya.

In: Drug Metabolism and Pharmacokinetics, Vol. 18, No. 3, 01.02.2003, p. 218-221.

Research output: Contribution to journalArticle

Saito, T, Egashira, M, Kiyotani, K, Fujieda, M, Yamazaki, H, Kiyohara, C, Kunitoh, H & Kamataki, T 2003, 'Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese', Drug Metabolism and Pharmacokinetics, vol. 18, no. 3, pp. 218-221. https://doi.org/10.2133/dmpk.18.218
Saito, Tetsuya ; Egashira, Mari ; Kiyotani, Kazuma ; Fujieda, Masaki ; Yamazaki, Hiroshi ; Kiyohara, Chikako ; Kunitoh, Hideo ; Kamataki, Tetsuya. / Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese. In: Drug Metabolism and Pharmacokinetics. 2003 ; Vol. 18, No. 3. pp. 218-221.
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AU - Yamazaki, Hiroshi

AU - Kiyohara, Chikako

AU - Kunitoh, Hideo

AU - Kamataki, Tetsuya

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N2 - We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile448Asn, Arg464Cys, and Arg477Trp and Pro492Arg, respectively) were as follows: SNP, 030212Saito001; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTC A ACCC ATCT-/TG AGTTCCT ACCT-3'. SNP, 030212Saito002; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTG AG A AGGTG AT / AT ATCTTTGGC AT-3'. SNP, 030212Saito003; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GAGACCGTTGCCC/TGCTGGGAGGTCT-3'. SNP, 030212Saito004; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' - ATCCTGCTGC A A C /TGGGTGG A ATTC A-3'. SNP, 030212Saito005; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' -TGG ACATG ACCCC /GC ATCT ATGGGCT-3'.

AB - We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile448Asn, Arg464Cys, and Arg477Trp and Pro492Arg, respectively) were as follows: SNP, 030212Saito001; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTC A ACCC ATCT-/TG AGTTCCT ACCT-3'. SNP, 030212Saito002; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTG AG A AGGTG AT / AT ATCTTTGGC AT-3'. SNP, 030212Saito003; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GAGACCGTTGCCC/TGCTGGGAGGTCT-3'. SNP, 030212Saito004; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' - ATCCTGCTGC A A C /TGGGTGG A ATTC A-3'. SNP, 030212Saito005; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' -TGG ACATG ACCCC /GC ATCT ATGGGCT-3'.

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