Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese

Tetsuya Saito, Mari Egashira, Kazuma Kiyotani, Masaki Fujieda, Hiroshi Yamazaki, Chikako Kiyohara, Hideo Kunitoh, Tetsuya Kamataki

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2 Citations (Scopus)

Abstract

We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile448Asn, Arg464Cys, and Arg477Trp and Pro492Arg, respectively) were as follows: SNP, 030212Saito001; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTC A ACCC ATCT-/TG AGTTCCT ACCT-3'. SNP, 030212Saito002; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTG AG A AGGTG AT / AT ATCTTTGGC AT-3'. SNP, 030212Saito003; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GAGACCGTTGCCC/TGCTGGGAGGTCT-3'. SNP, 030212Saito004; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' - ATCCTGCTGC A A C /TGGGTGG A ATTC A-3'. SNP, 030212Saito005; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' -TGG ACATG ACCCC /GC ATCT ATGGGCT-3'.

Original languageEnglish
Pages (from-to)218-221
Number of pages4
JournalDrug metabolism and pharmacokinetics
Volume18
Issue number3
DOIs
Publication statusPublished - Feb 1 2003

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

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    Saito, T., Egashira, M., Kiyotani, K., Fujieda, M., Yamazaki, H., Kiyohara, C., Kunitoh, H., & Kamataki, T. (2003). Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese. Drug metabolism and pharmacokinetics, 18(3), 218-221. https://doi.org/10.2133/dmpk.18.218