Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior

Jin Cui, Shigeru Matsuoka, Masanao Kinoshita, Nobuaki Matsumori, Fuminori Sato, Michio Murata, Jun Ando, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Abstract Three Raman probes of sphingomyelin (SM) were synthesized and evaluated for their applicability to imaging experiments. One probe containing a hydroxymethyl-1,3-butadiyne moiety in the polar head group showed strong scattering. The solid-state 2H NMR spectra of this probe in oriented bilayer membrane revealed excellent compatibility with natural SM in phase behavior since the probe undergoes phase separation to form raft-like liquid ordered (Lo) domains in the raft-mimicking mixed bilayers.

Original languageEnglish
Article number12310
Pages (from-to)2989-2994
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume23
Issue number13
DOIs
Publication statusPublished - Jan 1 2015

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Sphingomyelins
Membranes
Phase behavior
Phase separation
Nuclear magnetic resonance
Scattering
Imaging techniques
Liquids
Experiments

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior. / Cui, Jin; Matsuoka, Shigeru; Kinoshita, Masanao; Matsumori, Nobuaki; Sato, Fuminori; Murata, Michio; Ando, Jun; Yamakoshi, Hiroyuki; Dodo, Kosuke; Sodeoka, Mikiko.

In: Bioorganic and Medicinal Chemistry, Vol. 23, No. 13, 12310, 01.01.2015, p. 2989-2994.

Research output: Contribution to journalArticle

Cui, J, Matsuoka, S, Kinoshita, M, Matsumori, N, Sato, F, Murata, M, Ando, J, Yamakoshi, H, Dodo, K & Sodeoka, M 2015, 'Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior', Bioorganic and Medicinal Chemistry, vol. 23, no. 13, 12310, pp. 2989-2994. https://doi.org/10.1016/j.bmc.2015.05.014
Cui, Jin ; Matsuoka, Shigeru ; Kinoshita, Masanao ; Matsumori, Nobuaki ; Sato, Fuminori ; Murata, Michio ; Ando, Jun ; Yamakoshi, Hiroyuki ; Dodo, Kosuke ; Sodeoka, Mikiko. / Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior. In: Bioorganic and Medicinal Chemistry. 2015 ; Vol. 23, No. 13. pp. 2989-2994.
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