Novel silver-loaded semi-interpenetrating polymer network gel films with antibacterial activity

Reddy Thatiparti Thimma, Arihiro Kano, Maruyama Atsushi, Atsushi Takahara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Novel semi-interpenetrating polymer networks (SIPNs) based on segmented polyurethane-urea and poly(N-isopropylacrylamide-co-acrylic acid-co- butylmethacrylate) (poly(NIPAM-co-AA-BMA)) were synthesized for the fabrication of silver nanoparticles (AgNPs) in the SIPN system that could be useful for wound dressing applications. The obtained SIPN films, after neutralization, showed high swelling in aqueous environments and good mechanical properties in both dry and hydrated states. Analysis of the dried SIPN films by differential scanning calorimetry and dynamic viscoelastic measurements revealed the presence of crosslinked copolymers as well as homopolymers in the SIPN system. The neutralized swollen SIPN film, coordinated with the silver ions (Ag+) that were incorporated into it. AgNPs were subsequently formed by the reduction of Ag+. The formation of AgNPs was characterized by UV-visible spectroscopy, atomic force microscopy, wide-angle X-ray diffraction, and thermogravimetric analysis (TGA). Bactericidal activity tests revealed a distinct zone of microbial inhibition within and around the silver-doped SIPN films.

Original languageEnglish
Pages (from-to)4950-4962
Number of pages13
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume47
Issue number19
DOIs
Publication statusPublished - Oct 1 2009

Fingerprint

Interpenetrating polymer networks
Silver
Gels
Polyurethanes
Homopolymerization
Urea
X ray diffraction analysis
Acrylics
Swelling
Thermogravimetric analysis
Differential scanning calorimetry
Atomic force microscopy
Copolymers
Spectroscopy
Ions
Nanoparticles
Fabrication
Mechanical properties
Acids

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

Novel silver-loaded semi-interpenetrating polymer network gel films with antibacterial activity. / Thimma, Reddy Thatiparti; Kano, Arihiro; Atsushi, Maruyama; Takahara, Atsushi.

In: Journal of Polymer Science, Part A: Polymer Chemistry, Vol. 47, No. 19, 01.10.2009, p. 4950-4962.

Research output: Contribution to journalArticle

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