Abstract
Ynolates have been synthesized via the thermally-induced cleavage of ester dianions. The key intermediates, ester dianions, were generated from α-bromocarboxylic acid ester enolates via lithium halogen exchange. α,α-Dibromocarboxylic acid ester also gives lithium amide free ynolates by addition of tert-BuLi. The reactions of ynolates, generated by this novel and convenient method, with aldehydes to give β-lactons are discussed.
Original language | English |
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Pages (from-to) | 2411-2422 |
Number of pages | 12 |
Journal | Tetrahedron |
Volume | 54 |
Issue number | 11 |
DOIs | |
Publication status | Published - Mar 12 1998 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry