NRF2 Activation inhibits both tgf- β 1- and il-13-mediated periostin expression in fibroblasts: Benefit of cinnamaldehyde for antifibrotic treatment

Yasutaka Mitamura, Mika Murai, Chikage Mitoma, Masutaka Furue

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Systemic fibrosing or sclerotic disorders are life-threatening, but only very limited treatment modalities are available for them. In recent years, periostin (POSTN), a major extracellular matrix component, was established by several studies as a novel key player in the progression of systemic fibrotic disease. In this research, we revealed the involvement of oxidative stress in the expression of POSTN induced by TGF-β1 and IL-13 in dermal fibroblasts. We found that the antioxidant cinnamaldehyde activated the NRF2/HMOX1 pathway. Cinnamaldehyde also alleviated TGF-β1- and IL-13-mediated production of reactive oxygen species and subsequent POSTN upregulation in dermal fibroblasts. In contrast, NRF2 silencing abolished the cinnamaldehyde-mediated downregulation of POSTN. These results suggest that cinnamaldehyde is a broad inhibitor of POSTN expression covering both TGF-β1 and IL-13 signaling. Cinnamaldehyde may thus be beneficial for the treatment of systemic fibrotic diseases.

Original languageEnglish
Article number2475047
JournalOxidative medicine and cellular longevity
Volume2018
DOIs
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Cell Biology

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