TY - JOUR
T1 - Nuclear atypia grading score is a useful prognostic factor in papillary gastric adenocarcinoma
AU - Nakashima, Yuichiro
AU - Yao, Takashi
AU - Hirahashi, Minako
AU - Aishima, Shinichi
AU - Kakeji, Yoshihiro
AU - Maehara, Yoshihiko
AU - Tsuneyoshi, Masazumi
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Aims: To investigate nuclear atypical in papillary gastric adenocarcinoma (PGA). Method and results: Hundred cases of PGA were classified into two groups according to nuclear pleomorphism and nuclear polarity; these groups were designated as high nuclear grade and low nuclear grade. Correlations between nuclear grade and clinicopathological features were evaluated for prognostic value. In order to evaluate which types of biological factors influence nuclear atypia, the expression of gastric-type mucin phenotype, p53, HER2 and Ki-67 detected by immunohistochemistry and DNA ploidy detected by laser scanning cytometry. The high nuclear grade group correlated with deeper wall invasion, the presence of lymphatic and venous invasion and the positivity of lymph node metastasis. High nuclear grade was an independent prognostic factor for disease-free survival. Moreover, significant correlations were observed between high nuclear grade and positivity of gastric-type mucin phenotype, p53 and HER2 and DNA aneuploidy. Conclusion: Nuclear grade could be a new and useful morphological predictor for high malignant potential in PGA.
AB - Aims: To investigate nuclear atypical in papillary gastric adenocarcinoma (PGA). Method and results: Hundred cases of PGA were classified into two groups according to nuclear pleomorphism and nuclear polarity; these groups were designated as high nuclear grade and low nuclear grade. Correlations between nuclear grade and clinicopathological features were evaluated for prognostic value. In order to evaluate which types of biological factors influence nuclear atypia, the expression of gastric-type mucin phenotype, p53, HER2 and Ki-67 detected by immunohistochemistry and DNA ploidy detected by laser scanning cytometry. The high nuclear grade group correlated with deeper wall invasion, the presence of lymphatic and venous invasion and the positivity of lymph node metastasis. High nuclear grade was an independent prognostic factor for disease-free survival. Moreover, significant correlations were observed between high nuclear grade and positivity of gastric-type mucin phenotype, p53 and HER2 and DNA aneuploidy. Conclusion: Nuclear grade could be a new and useful morphological predictor for high malignant potential in PGA.
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U2 - 10.1111/j.1365-2559.2011.04035.x
DO - 10.1111/j.1365-2559.2011.04035.x
M3 - Article
C2 - 22092395
AN - SCOPUS:81555209825
VL - 59
SP - 841
EP - 849
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 5
ER -