Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh

Akio Yamasaki, Chizu Kameda, Rui Xu, Haruo Tanaka, Takehiko Tasaka, Nobuhito Chikazawa, Hiroyuki Suzuki, Takashi Morisaki, Makoto Kubo, Hideya Onishi, Masao Tanaka, M. Katano

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Recently, it was reported that Hh signaling is activated in tumor stromal cells but not in tumor cells themselves and that stromal cells may play a role in the proliferation of cancer cells. This suggests the possibility that stromal cells have an important role in the proliferation of tumor cells that may be mediated through Hh signaling. In this report, we present for the first time that inflammationstimulated monocytes produce Shh through activation of the NF-κB signaling pathway, and that the Shh produced promotes the proliferation of pancreatic cancer cells in a paracrine manner through Hh signaling.

Original languageEnglish
Pages (from-to)675-686
Number of pages12
JournalCancer Immunology, Immunotherapy
Volume59
Issue number5
DOIs
Publication statusPublished - May 1 2010

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Pancreatic Neoplasms
Monocytes
Stromal Cells
Neoplasms
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

Cite this

Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh. / Yamasaki, Akio; Kameda, Chizu; Xu, Rui; Tanaka, Haruo; Tasaka, Takehiko; Chikazawa, Nobuhito; Suzuki, Hiroyuki; Morisaki, Takashi; Kubo, Makoto; Onishi, Hideya; Tanaka, Masao; Katano, M.

In: Cancer Immunology, Immunotherapy, Vol. 59, No. 5, 01.05.2010, p. 675-686.

Research output: Contribution to journalArticle

Yamasaki, A, Kameda, C, Xu, R, Tanaka, H, Tasaka, T, Chikazawa, N, Suzuki, H, Morisaki, T, Kubo, M, Onishi, H, Tanaka, M & Katano, M 2010, 'Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh', Cancer Immunology, Immunotherapy, vol. 59, no. 5, pp. 675-686. https://doi.org/10.1007/s00262-009-0783-7
Yamasaki, Akio ; Kameda, Chizu ; Xu, Rui ; Tanaka, Haruo ; Tasaka, Takehiko ; Chikazawa, Nobuhito ; Suzuki, Hiroyuki ; Morisaki, Takashi ; Kubo, Makoto ; Onishi, Hideya ; Tanaka, Masao ; Katano, M. / Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh. In: Cancer Immunology, Immunotherapy. 2010 ; Vol. 59, No. 5. pp. 675-686.
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