Nucleotide 2′,3′-cyclic monophosphokinase action of streptomyces nucleotide 3′-pyrophosphokinase

Jun Ichiro Mukai, Akinori Hirashima, Takeshi Mikuniya

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Streptomyces nucleotide 3′-pyrophosphokinase, formerly known to synthesize a variety of 3′-pyrophospho nucleotides by 5′-β,γ-pyrophosphoryl transfer from ATP, ATP 3′-pyrophosphate, and dATP, can also synthesize 2′,3′-cyclic monophospho nucleotides using diadenosine 5′,5′-poly (tri, tetra, and penta) phosphates as the phosphate donor. The examples are pA > p, ppA > p, pG > p, and CpG > p. Transient formation of an -N(3′)pp(5′)A structure via ADP transfer from the donor followed by AMP elimination is proposed as their synthetic mechanism.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalAgricultural and Biological Chemistry
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 1 1991

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nucleotide pyrophosphokinase
Diphosphotransferases
Streptomyces
Nucleotides
Adenosine Triphosphate
nucleotides
Phosphates
phosphates
Pentas
cyclic nucleotides
Rubiaceae
Cyclic Nucleotides
pyrophosphates
Adenosine Monophosphate
Adenosine Diphosphate

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Nucleotide 2′,3′-cyclic monophosphokinase action of streptomyces nucleotide 3′-pyrophosphokinase. / Mukai, Jun Ichiro; Hirashima, Akinori; Mikuniya, Takeshi.

In: Agricultural and Biological Chemistry, Vol. 55, No. 1, 01.01.1991, p. 117-122.

Research output: Contribution to journalArticle

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