Nukacin ISK-1, a bacteriostatic lantibiotic

Sikder M. Asaduzzaman, Jun Ichi Nagao, Hiroshi Iida, Takeshi Zendo, Jiro Nakayama, Kenji Sonomoto

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We determined the mode of action of nukacin ISK-1. It did not cause membrane potential dissipation or the efflux of ATP or K+ ions from the cells of a sensitive bacterial strain; however, it blocked the membrane depolarization activity of nisin. Nukacin ISK-1-treated cells had single arrangements of cells without the formation of a complete septum. A remarkable reduction in cell wall width was also observed, but cytoplasmic content was unaffected. We concluded that nukacin ISK-1 is bacteriostatic.

Original languageEnglish
Pages (from-to)3595-3598
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number8
DOIs
Publication statusPublished - Aug 1 2009

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Bacteriocins
Nisin
Membrane Potentials
Cell Wall
Adenosine Triphosphate
Ions
Membranes
nukacin ISK-1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Nukacin ISK-1, a bacteriostatic lantibiotic. / Asaduzzaman, Sikder M.; Nagao, Jun Ichi; Iida, Hiroshi; Zendo, Takeshi; Nakayama, Jiro; Sonomoto, Kenji.

In: Antimicrobial Agents and Chemotherapy, Vol. 53, No. 8, 01.08.2009, p. 3595-3598.

Research output: Contribution to journalArticle

Asaduzzaman, Sikder M. ; Nagao, Jun Ichi ; Iida, Hiroshi ; Zendo, Takeshi ; Nakayama, Jiro ; Sonomoto, Kenji. / Nukacin ISK-1, a bacteriostatic lantibiotic. In: Antimicrobial Agents and Chemotherapy. 2009 ; Vol. 53, No. 8. pp. 3595-3598.
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