Nukacin ISK-1, a bacteriostatic lantibiotic

Sikder M. Asaduzzaman, Jun Ichi Nagao, Hiroshi Iida, Takeshi Zendo, Jiro Nakayama, Kenji Sonomoto

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


We determined the mode of action of nukacin ISK-1. It did not cause membrane potential dissipation or the efflux of ATP or K+ ions from the cells of a sensitive bacterial strain; however, it blocked the membrane depolarization activity of nisin. Nukacin ISK-1-treated cells had single arrangements of cells without the formation of a complete septum. A remarkable reduction in cell wall width was also observed, but cytoplasmic content was unaffected. We concluded that nukacin ISK-1 is bacteriostatic.

Original languageEnglish
Pages (from-to)3595-3598
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number8
Publication statusPublished - Aug 2009

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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