Numerical and Experimental Quantification of the Performance of Microreactors for Scaling-up Fast Chemical Reactions

Syusaku Asano, Shota Yatabe, Taisuke Maki, Kazuhiro Mae

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Microreactors have been utilized for controlling fast chemical reactions. However, the scale-up strategy for fast reactions is not established enough due to the difficulty in quantifying the effect of the reactor size on the mixing performance, heat removal, and observable reaction rate. We present a chart for analyzing the effect of the mixing rate on the observable kinetic constant and a chart for estimating the temperature increase in the reactor. By using these charts, the validity of the rate analysis and the maximum reactor diameter, which control the reaction temperature, were determined. Commercial computational fluid dynamics (CFD) software was employed to solve the partial differential equations and to build the charts, and experiments were conducted to validate the results. We demonstrated the concept by using the ultrafast organolithium reaction in milliseconds. The product throughput was increased eight times with a reactor diameter that was twice as wide as the original reactor.

Original languageEnglish
Pages (from-to)807-817
Number of pages11
JournalOrganic Process Research and Development
Volume23
Issue number5
DOIs
Publication statusPublished - May 17 2019
Externally publishedYes

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Chemical reactions
charts
chemical reactions
reactors
scaling
Partial differential equations
Reaction rates
Computational fluid dynamics
Throughput
Temperature
Kinetics
computational fluid dynamics
partial differential equations
Experiments
reaction kinetics
estimating
computer programs
heat
temperature
kinetics

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Numerical and Experimental Quantification of the Performance of Microreactors for Scaling-up Fast Chemical Reactions. / Asano, Syusaku; Yatabe, Shota; Maki, Taisuke; Mae, Kazuhiro.

In: Organic Process Research and Development, Vol. 23, No. 5, 17.05.2019, p. 807-817.

Research output: Contribution to journalArticle

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