TY - JOUR
T1 - Numerical prediction of tissue dosimetry in respiratory tract using computer simulated person integrated with physiologically based pharmacokinetic–computational fluid dynamics hybrid analysis
AU - Yoo, Sung Jun
AU - Ito, Kazuhide
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was partially supported by a Grant-in-Aid for Scientific Research (JSPS KAKENHI for Scientific Research (B), 15H04086 and Category of Challenging Exploratory Research, 16K14346).
Publisher Copyright:
© The Author(s) 2017.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Indoor environmental quality, e.g. air quality and thermal environments, has a potential impact on residents in indoors. Development of a computer simulated person (CSP) for indoor computational fluid dynamics (CFD) simulation can contribute to the improvement of design and prediction method regarding the interaction between indoor air/thermal environmental factors and human responses. In this study, a CSP integrated with a virtual airway was developed and used to estimate inhalation exposure in an indoor environment. The virtual airway is a numerical respiratory tract model for CFD simulation that reproduces detailed geometry from the nasal/oral cavity to the bronchial tubes by way of the trachea. Physiologically based pharmacokinetic (PBPK)-CFD hybrid analysis is also integrated into the CSP. Through the coupled simulation of PBPK-CFD-CSP analysis, inhalation exposure under steady state conditions where formaldehyde was emitted from floor material was analysed and respiratory tissue doses and their distributions of inhaled contaminants are discussed quantitatively.
AB - Indoor environmental quality, e.g. air quality and thermal environments, has a potential impact on residents in indoors. Development of a computer simulated person (CSP) for indoor computational fluid dynamics (CFD) simulation can contribute to the improvement of design and prediction method regarding the interaction between indoor air/thermal environmental factors and human responses. In this study, a CSP integrated with a virtual airway was developed and used to estimate inhalation exposure in an indoor environment. The virtual airway is a numerical respiratory tract model for CFD simulation that reproduces detailed geometry from the nasal/oral cavity to the bronchial tubes by way of the trachea. Physiologically based pharmacokinetic (PBPK)-CFD hybrid analysis is also integrated into the CSP. Through the coupled simulation of PBPK-CFD-CSP analysis, inhalation exposure under steady state conditions where formaldehyde was emitted from floor material was analysed and respiratory tissue doses and their distributions of inhaled contaminants are discussed quantitatively.
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U2 - 10.1177/1420326X17694475
DO - 10.1177/1420326X17694475
M3 - Article
AN - SCOPUS:85042030037
SN - 1420-326X
VL - 27
SP - 877
EP - 889
JO - Indoor and Built Environment
JF - Indoor and Built Environment
IS - 7
ER -