Obesity induced by abnormality in leptin receptor and melanocortin-4 receptor

Mitsuyo Shintani, Yoshihiro Ogawa, Kazuwa Nakao

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Obesity is a multifactorial disease that arises from complex interactions between genetic predisposition and environmental factors. It increases a risk of cardiovascular and metabolic diseases such as diabetes, hypertension, and hyperlipidemia. Recent molecular genetic studies have disclosed some monogenic forms of obesity in humans. Leptin directly exerts its anorexigenic effects on hypothalamic arcuate nucleus. alpha-melanocyte stimulating hormone (alpha-MSH) derived from proopiomelanocortin (POMC) and melanocortin-4 receptor (MC4-R) have been reported to be involved in the downstream of leptin actions. In this paper, we summarize the clinical characteristics and the mechanisms of obesity caused by genetic abnormalities in leptin receptor and melanocortin-4 receptor.

Original languageEnglish
Pages (from-to)404-409
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Volume60
Issue number2
Publication statusPublished - Jan 1 2002
Externally publishedYes

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Receptor, Melanocortin, Type 4
Leptin Receptors
Obesity
Leptin
alpha-MSH
Pro-Opiomelanocortin
Arcuate Nucleus of Hypothalamus
Metabolic Diseases
Genetic Predisposition to Disease
Hyperlipidemias
Molecular Biology
Cardiovascular Diseases
Hypertension

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Obesity induced by abnormality in leptin receptor and melanocortin-4 receptor. / Shintani, Mitsuyo; Ogawa, Yoshihiro; Nakao, Kazuwa.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 60, No. 2, 01.01.2002, p. 404-409.

Research output: Contribution to journalReview article

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