Obesity, weight gain and risk of colon adenomas in Japanese men

Suminori Kono, Koichi Handa, Hitomi Hayabuchi, Chikako Kiyohara, Hisako Inoue, Tomomi Marugame, Sachiko Shinomiya, Hiroaki Hamada, Kazuya Onuma, Hiroko Koga

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Obesity has been related to increased risk of colon cancer or adenomas, but the epidemiologic findings are not entirely consistent. We examined the relation of not only body mass index (BMI) but also waist-to-hip ratio (WHR) and weight gain to colon adenoma risk in men who received a preretirement health examination at the Japan Self Defense Forces (SDF) Fukuoka and Kumamoto Hospitals during the period from 1995 to 1996. In the series of 803 men at age 47-55 years, 189 cases of colon adenomas and 226 controls with normal total colonoscopy were identified. Weight at 10 years before was ascertained by referring to the recorded data. After allowance for hospital, rank in the SDF, smoking and alcohol use, weight gain over the past 10 years was significantly associated with increased risk of colon adenomas (odds ratio for ≥ 6 kg versus ≤ -2 kg = 2.2; 95% confidence interval 1.0-4.8). High BMI and high WHR were each associated with increased risk, but only WHR was related to the risk independently of weight gain. In particular, weight gain accompanied with a high WHR was associated with a significant increase in the risk. Men with high physical activity tended to have lower risk. Associations with obesity-related variables and physical activity were not materially differential as regards the location and size of adenoma. The findings indicate that weight gain in middle age leading to abdominal obesity increases the risk of colon adenomas, and consequently of colon cancer.

Original languageEnglish
Pages (from-to)805-811
Number of pages7
JournalJapanese Journal of Cancer Research
Volume90
Issue number8
DOIs
Publication statusPublished - Aug 1999

Fingerprint

Adenoma
Weight Gain
Colon
Obesity
Waist-Hip Ratio
Colonic Neoplasms
Body Mass Index
Exercise
Abdominal Obesity
Colonoscopy
Japan
Smoking
Odds Ratio
Alcohols
Confidence Intervals
Weights and Measures
Health

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Obesity, weight gain and risk of colon adenomas in Japanese men. / Kono, Suminori; Handa, Koichi; Hayabuchi, Hitomi; Kiyohara, Chikako; Inoue, Hisako; Marugame, Tomomi; Shinomiya, Sachiko; Hamada, Hiroaki; Onuma, Kazuya; Koga, Hiroko.

In: Japanese Journal of Cancer Research, Vol. 90, No. 8, 08.1999, p. 805-811.

Research output: Contribution to journalArticle

Kono, S, Handa, K, Hayabuchi, H, Kiyohara, C, Inoue, H, Marugame, T, Shinomiya, S, Hamada, H, Onuma, K & Koga, H 1999, 'Obesity, weight gain and risk of colon adenomas in Japanese men', Japanese Journal of Cancer Research, vol. 90, no. 8, pp. 805-811. https://doi.org/10.1111/j.1349-7006.1999.tb00819.x
Kono, Suminori ; Handa, Koichi ; Hayabuchi, Hitomi ; Kiyohara, Chikako ; Inoue, Hisako ; Marugame, Tomomi ; Shinomiya, Sachiko ; Hamada, Hiroaki ; Onuma, Kazuya ; Koga, Hiroko. / Obesity, weight gain and risk of colon adenomas in Japanese men. In: Japanese Journal of Cancer Research. 1999 ; Vol. 90, No. 8. pp. 805-811.
@article{cad65f526e7b4524b1779a14523745bf,
title = "Obesity, weight gain and risk of colon adenomas in Japanese men",
abstract = "Obesity has been related to increased risk of colon cancer or adenomas, but the epidemiologic findings are not entirely consistent. We examined the relation of not only body mass index (BMI) but also waist-to-hip ratio (WHR) and weight gain to colon adenoma risk in men who received a preretirement health examination at the Japan Self Defense Forces (SDF) Fukuoka and Kumamoto Hospitals during the period from 1995 to 1996. In the series of 803 men at age 47-55 years, 189 cases of colon adenomas and 226 controls with normal total colonoscopy were identified. Weight at 10 years before was ascertained by referring to the recorded data. After allowance for hospital, rank in the SDF, smoking and alcohol use, weight gain over the past 10 years was significantly associated with increased risk of colon adenomas (odds ratio for ≥ 6 kg versus ≤ -2 kg = 2.2; 95{\%} confidence interval 1.0-4.8). High BMI and high WHR were each associated with increased risk, but only WHR was related to the risk independently of weight gain. In particular, weight gain accompanied with a high WHR was associated with a significant increase in the risk. Men with high physical activity tended to have lower risk. Associations with obesity-related variables and physical activity were not materially differential as regards the location and size of adenoma. The findings indicate that weight gain in middle age leading to abdominal obesity increases the risk of colon adenomas, and consequently of colon cancer.",
author = "Suminori Kono and Koichi Handa and Hitomi Hayabuchi and Chikako Kiyohara and Hisako Inoue and Tomomi Marugame and Sachiko Shinomiya and Hiroaki Hamada and Kazuya Onuma and Hiroko Koga",
year = "1999",
month = "8",
doi = "10.1111/j.1349-7006.1999.tb00819.x",
language = "English",
volume = "90",
pages = "805--811",
journal = "Cancer Science",
issn = "1347-9032",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Obesity, weight gain and risk of colon adenomas in Japanese men

AU - Kono, Suminori

AU - Handa, Koichi

AU - Hayabuchi, Hitomi

AU - Kiyohara, Chikako

AU - Inoue, Hisako

AU - Marugame, Tomomi

AU - Shinomiya, Sachiko

AU - Hamada, Hiroaki

AU - Onuma, Kazuya

AU - Koga, Hiroko

PY - 1999/8

Y1 - 1999/8

N2 - Obesity has been related to increased risk of colon cancer or adenomas, but the epidemiologic findings are not entirely consistent. We examined the relation of not only body mass index (BMI) but also waist-to-hip ratio (WHR) and weight gain to colon adenoma risk in men who received a preretirement health examination at the Japan Self Defense Forces (SDF) Fukuoka and Kumamoto Hospitals during the period from 1995 to 1996. In the series of 803 men at age 47-55 years, 189 cases of colon adenomas and 226 controls with normal total colonoscopy were identified. Weight at 10 years before was ascertained by referring to the recorded data. After allowance for hospital, rank in the SDF, smoking and alcohol use, weight gain over the past 10 years was significantly associated with increased risk of colon adenomas (odds ratio for ≥ 6 kg versus ≤ -2 kg = 2.2; 95% confidence interval 1.0-4.8). High BMI and high WHR were each associated with increased risk, but only WHR was related to the risk independently of weight gain. In particular, weight gain accompanied with a high WHR was associated with a significant increase in the risk. Men with high physical activity tended to have lower risk. Associations with obesity-related variables and physical activity were not materially differential as regards the location and size of adenoma. The findings indicate that weight gain in middle age leading to abdominal obesity increases the risk of colon adenomas, and consequently of colon cancer.

AB - Obesity has been related to increased risk of colon cancer or adenomas, but the epidemiologic findings are not entirely consistent. We examined the relation of not only body mass index (BMI) but also waist-to-hip ratio (WHR) and weight gain to colon adenoma risk in men who received a preretirement health examination at the Japan Self Defense Forces (SDF) Fukuoka and Kumamoto Hospitals during the period from 1995 to 1996. In the series of 803 men at age 47-55 years, 189 cases of colon adenomas and 226 controls with normal total colonoscopy were identified. Weight at 10 years before was ascertained by referring to the recorded data. After allowance for hospital, rank in the SDF, smoking and alcohol use, weight gain over the past 10 years was significantly associated with increased risk of colon adenomas (odds ratio for ≥ 6 kg versus ≤ -2 kg = 2.2; 95% confidence interval 1.0-4.8). High BMI and high WHR were each associated with increased risk, but only WHR was related to the risk independently of weight gain. In particular, weight gain accompanied with a high WHR was associated with a significant increase in the risk. Men with high physical activity tended to have lower risk. Associations with obesity-related variables and physical activity were not materially differential as regards the location and size of adenoma. The findings indicate that weight gain in middle age leading to abdominal obesity increases the risk of colon adenomas, and consequently of colon cancer.

UR - http://www.scopus.com/inward/record.url?scp=0032825771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032825771&partnerID=8YFLogxK

U2 - 10.1111/j.1349-7006.1999.tb00819.x

DO - 10.1111/j.1349-7006.1999.tb00819.x

M3 - Article

C2 - 10543250

AN - SCOPUS:0032825771

VL - 90

SP - 805

EP - 811

JO - Cancer Science

JF - Cancer Science

SN - 1347-9032

IS - 8

ER -