Observing the repulsion layers on blood-compatible polymer-grafted interfaces by frequency modulation atomic force microscopy

Daiki Murakami, Shin nosuke Nishimura, Yukiko Tanaka, Masaru Tanaka

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Blood-compatible materials that do not promote reactions in contact with human blood are required to support emerging medical technologies. The interfaces of poly(2-methoxyethyl acrylate) (PMEA), a blood-compatible polymer, and its analogues were investigated by frequency modulation atomic force microscopy (FM-AFM). The grafted polymers exhibited phase separation into polymer-rich and water-rich domains. Thin repulsive layers of hydrated polymer chains were observed in the water-rich domains of the blood-compatible polymers; on the other hand, such layers were not observed for the non-blood-compatible polymers. We report for the first time that FM-AFM enables characteristic repulsive layers composed of hydrated polymer chains in water-rich domains to be observed, which is a significant design factor for blood-compatible polymers.

Original languageEnglish
Article number112596
JournalBiomaterials Advances
Volume133
DOIs
Publication statusPublished - Feb 2022

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biomaterials
  • Bioengineering

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