Occupational risk factors for Parkinson's disease: A case-control study in Japan

Keiko Tanaka, Yoshihiro Miyake, Wakaba Fukushima, Satoshi Sasaki, Chikako Kiyohara, Yoshio Tsuboi, Tatsuo Yamada, Tomoko Oeda, Takami Miki, Nobutoshi Kawamura, Nobutaka Sakae, Hidenao Fukuyama, Yoshio Hirota, Masaki Nagai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The evidence for associations between occupational factors and the risk of Parkinson's disease (PD) is inconsistent. We assessed the risk of PD associated with various occupational factors in Japan.Methods: We examined 249 cases within 6 years of onset of PD. Control subjects were 369 inpatients and outpatients without neurodegenerative disease. Information on occupational factors was obtained from a self-administered questionnaire. Relative risks of PD were estimated using odds ratios (ORs) and 95% confidence intervals (CIs) based on logistic regression. Adjustments were made for gender, age, region of residence, educational level, and pack-years of smoking.Results: Working in a professional or technical occupation tended to be inversely related to the risk of PD: adjusted OR was 0.59 (95% CI: 0.32-1.06, P = 0.08). According to a stratified analysis by gender, the decreased risk of PD for persons in professional or technical occupations was statistically significant only for men. Adjusted ORs for a professional or technical occupation among men and women were 0.22 (95% CI: 0.06-0.67) and 0.99 (0.47-2.07), respectively, and significant interaction was observed (P = 0.048 for homogeneity of OR). In contrast, risk estimates for protective service occupations and transport or communications were increased, although the results were not statistically significant: adjusted ORs were 2.73 (95% CI: 0.56-14.86) and 1.74 (95% CI: 0.65-4.74), respectively. No statistical significance was seen in data concerning exposure to occupational agents and the risk of PD, although roughly a 2-fold increase in OR was observed for workers exposed to stone or sand.Conclusion: The results of our study suggest that occupational factors do not play a substantial etiologic role in this population. However, among men, professional or technical occupations may decrease the risk of PD.

Original languageEnglish
Article number83
JournalBMC neurology
Volume11
DOIs
Publication statusPublished - Jul 7 2011

Fingerprint

Parkinson Disease
Case-Control Studies
Japan
Occupations
Odds Ratio
Confidence Intervals
Social Adjustment
Occupational Exposure
Neurodegenerative Diseases
Inpatients
Outpatients
Logistic Models
Smoking
Communication
Population

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Tanaka, K., Miyake, Y., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., ... Nagai, M. (2011). Occupational risk factors for Parkinson's disease: A case-control study in Japan. BMC neurology, 11, [83]. https://doi.org/10.1186/1471-2377-11-83

Occupational risk factors for Parkinson's disease : A case-control study in Japan. / Tanaka, Keiko; Miyake, Yoshihiro; Fukushima, Wakaba; Sasaki, Satoshi; Kiyohara, Chikako; Tsuboi, Yoshio; Yamada, Tatsuo; Oeda, Tomoko; Miki, Takami; Kawamura, Nobutoshi; Sakae, Nobutaka; Fukuyama, Hidenao; Hirota, Yoshio; Nagai, Masaki.

In: BMC neurology, Vol. 11, 83, 07.07.2011.

Research output: Contribution to journalArticle

Tanaka, K, Miyake, Y, Fukushima, W, Sasaki, S, Kiyohara, C, Tsuboi, Y, Yamada, T, Oeda, T, Miki, T, Kawamura, N, Sakae, N, Fukuyama, H, Hirota, Y & Nagai, M 2011, 'Occupational risk factors for Parkinson's disease: A case-control study in Japan', BMC neurology, vol. 11, 83. https://doi.org/10.1186/1471-2377-11-83
Tanaka, Keiko ; Miyake, Yoshihiro ; Fukushima, Wakaba ; Sasaki, Satoshi ; Kiyohara, Chikako ; Tsuboi, Yoshio ; Yamada, Tatsuo ; Oeda, Tomoko ; Miki, Takami ; Kawamura, Nobutoshi ; Sakae, Nobutaka ; Fukuyama, Hidenao ; Hirota, Yoshio ; Nagai, Masaki. / Occupational risk factors for Parkinson's disease : A case-control study in Japan. In: BMC neurology. 2011 ; Vol. 11.
@article{0e5d958d57cb4f09895024246ed76c51,
title = "Occupational risk factors for Parkinson's disease: A case-control study in Japan",
abstract = "Background: The evidence for associations between occupational factors and the risk of Parkinson's disease (PD) is inconsistent. We assessed the risk of PD associated with various occupational factors in Japan.Methods: We examined 249 cases within 6 years of onset of PD. Control subjects were 369 inpatients and outpatients without neurodegenerative disease. Information on occupational factors was obtained from a self-administered questionnaire. Relative risks of PD were estimated using odds ratios (ORs) and 95{\%} confidence intervals (CIs) based on logistic regression. Adjustments were made for gender, age, region of residence, educational level, and pack-years of smoking.Results: Working in a professional or technical occupation tended to be inversely related to the risk of PD: adjusted OR was 0.59 (95{\%} CI: 0.32-1.06, P = 0.08). According to a stratified analysis by gender, the decreased risk of PD for persons in professional or technical occupations was statistically significant only for men. Adjusted ORs for a professional or technical occupation among men and women were 0.22 (95{\%} CI: 0.06-0.67) and 0.99 (0.47-2.07), respectively, and significant interaction was observed (P = 0.048 for homogeneity of OR). In contrast, risk estimates for protective service occupations and transport or communications were increased, although the results were not statistically significant: adjusted ORs were 2.73 (95{\%} CI: 0.56-14.86) and 1.74 (95{\%} CI: 0.65-4.74), respectively. No statistical significance was seen in data concerning exposure to occupational agents and the risk of PD, although roughly a 2-fold increase in OR was observed for workers exposed to stone or sand.Conclusion: The results of our study suggest that occupational factors do not play a substantial etiologic role in this population. However, among men, professional or technical occupations may decrease the risk of PD.",
author = "Keiko Tanaka and Yoshihiro Miyake and Wakaba Fukushima and Satoshi Sasaki and Chikako Kiyohara and Yoshio Tsuboi and Tatsuo Yamada and Tomoko Oeda and Takami Miki and Nobutoshi Kawamura and Nobutaka Sakae and Hidenao Fukuyama and Yoshio Hirota and Masaki Nagai",
year = "2011",
month = "7",
day = "7",
doi = "10.1186/1471-2377-11-83",
language = "English",
volume = "11",
journal = "BMC Neurology",
issn = "1471-2377",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Occupational risk factors for Parkinson's disease

T2 - A case-control study in Japan

AU - Tanaka, Keiko

AU - Miyake, Yoshihiro

AU - Fukushima, Wakaba

AU - Sasaki, Satoshi

AU - Kiyohara, Chikako

AU - Tsuboi, Yoshio

AU - Yamada, Tatsuo

AU - Oeda, Tomoko

AU - Miki, Takami

AU - Kawamura, Nobutoshi

AU - Sakae, Nobutaka

AU - Fukuyama, Hidenao

AU - Hirota, Yoshio

AU - Nagai, Masaki

PY - 2011/7/7

Y1 - 2011/7/7

N2 - Background: The evidence for associations between occupational factors and the risk of Parkinson's disease (PD) is inconsistent. We assessed the risk of PD associated with various occupational factors in Japan.Methods: We examined 249 cases within 6 years of onset of PD. Control subjects were 369 inpatients and outpatients without neurodegenerative disease. Information on occupational factors was obtained from a self-administered questionnaire. Relative risks of PD were estimated using odds ratios (ORs) and 95% confidence intervals (CIs) based on logistic regression. Adjustments were made for gender, age, region of residence, educational level, and pack-years of smoking.Results: Working in a professional or technical occupation tended to be inversely related to the risk of PD: adjusted OR was 0.59 (95% CI: 0.32-1.06, P = 0.08). According to a stratified analysis by gender, the decreased risk of PD for persons in professional or technical occupations was statistically significant only for men. Adjusted ORs for a professional or technical occupation among men and women were 0.22 (95% CI: 0.06-0.67) and 0.99 (0.47-2.07), respectively, and significant interaction was observed (P = 0.048 for homogeneity of OR). In contrast, risk estimates for protective service occupations and transport or communications were increased, although the results were not statistically significant: adjusted ORs were 2.73 (95% CI: 0.56-14.86) and 1.74 (95% CI: 0.65-4.74), respectively. No statistical significance was seen in data concerning exposure to occupational agents and the risk of PD, although roughly a 2-fold increase in OR was observed for workers exposed to stone or sand.Conclusion: The results of our study suggest that occupational factors do not play a substantial etiologic role in this population. However, among men, professional or technical occupations may decrease the risk of PD.

AB - Background: The evidence for associations between occupational factors and the risk of Parkinson's disease (PD) is inconsistent. We assessed the risk of PD associated with various occupational factors in Japan.Methods: We examined 249 cases within 6 years of onset of PD. Control subjects were 369 inpatients and outpatients without neurodegenerative disease. Information on occupational factors was obtained from a self-administered questionnaire. Relative risks of PD were estimated using odds ratios (ORs) and 95% confidence intervals (CIs) based on logistic regression. Adjustments were made for gender, age, region of residence, educational level, and pack-years of smoking.Results: Working in a professional or technical occupation tended to be inversely related to the risk of PD: adjusted OR was 0.59 (95% CI: 0.32-1.06, P = 0.08). According to a stratified analysis by gender, the decreased risk of PD for persons in professional or technical occupations was statistically significant only for men. Adjusted ORs for a professional or technical occupation among men and women were 0.22 (95% CI: 0.06-0.67) and 0.99 (0.47-2.07), respectively, and significant interaction was observed (P = 0.048 for homogeneity of OR). In contrast, risk estimates for protective service occupations and transport or communications were increased, although the results were not statistically significant: adjusted ORs were 2.73 (95% CI: 0.56-14.86) and 1.74 (95% CI: 0.65-4.74), respectively. No statistical significance was seen in data concerning exposure to occupational agents and the risk of PD, although roughly a 2-fold increase in OR was observed for workers exposed to stone or sand.Conclusion: The results of our study suggest that occupational factors do not play a substantial etiologic role in this population. However, among men, professional or technical occupations may decrease the risk of PD.

UR - http://www.scopus.com/inward/record.url?scp=80052627987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052627987&partnerID=8YFLogxK

U2 - 10.1186/1471-2377-11-83

DO - 10.1186/1471-2377-11-83

M3 - Article

C2 - 21733194

AN - SCOPUS:80052627987

VL - 11

JO - BMC Neurology

JF - BMC Neurology

SN - 1471-2377

M1 - 83

ER -