Octacalcium phosphate: A potential scaffold material for controlling activity of bone-related cells in vitro

Osamu Suzuki, Takahisa Anada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

We have previously established a wet synthesis method of octacalcium phosphate (OCP) in a relatively large scale and found that OCP enhances bone formation more than synthetic hydroxyapatite (HA) if implanted onto bone surface and various bone defects. The present paper reviews, based on our studies, as to how OCP controls in vitro cellular activities of bone-related cells, such as bone marrow stromal cells, and how OCP enhances bone repair in critical sized bone defect experimentally created in animal models. OCP tends to progressively convert to HA in culture media and in rat calvaria defects. OCP is capable of enhancing in vitro osteoblast differentiation and osteoclast formation in the presence of osteoblasts. Recent our studies also indicated that OCP enhances odontoblast differentiation while suppresses chondrogenic differentiation. The physicochemical properties, such as chemical composition and adsorption affinity of serum proteins, vary depending on the advancement of conversion from OCP to HA, which suggests that the change on the surface property during the conversion of OCP may affect the cellular responses in vitro and tissue reaction in vivo. OCP could be used as a scaffold material that can control the activity of bone-related cells.

Original languageEnglish
Title of host publicationTHERMEC 2013
EditorsB. Mishra, Mihail. Ionescu, T. Chandra
PublisherTrans Tech Publications Ltd
Pages1366-1371
Number of pages6
ISBN (Print)9783038350736
Publication statusPublished - Jan 1 2014
Externally publishedYes
Event8th International Conference on Processing and Manufacturing of Advanced Materials, THERMEC 2013 - Las Vegas, NV, United States
Duration: Dec 2 2013Dec 6 2013

Publication series

NameMaterials Science Forum
Volume783-786
ISSN (Print)0255-5476
ISSN (Electronic)1662-9752

Other

Other8th International Conference on Processing and Manufacturing of Advanced Materials, THERMEC 2013
CountryUnited States
CityLas Vegas, NV
Period12/2/1312/6/13

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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