Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation

Takashi Saito, Katsuji Shinagawa, Katsuto Takenaka, Keitaro Matsuo, Tadashi Yoshino, Katsuyuki Kiura, Kenji Niiya, Mine Harada

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A 26-year-old woman with acute myeloid leukemia underwent allogeneic peripheral blood stem cell transplantation from an HLA-identical brother. Eighteen days after transplantation, the patient developed grade II acute graft-versus-host disease (GVHD) and was treated with corticosteroids. On day 38, the patient complained of eye pain and lacrimation. A slitlamp examination revealed corneal ulcers and pseudomembranous formation in both eyes. Histologic and immunohistochemical examinations of the pseudomembrane disclosed an infiltrate dominated by T cells. A cytogenetic study of the pseudomembrane by fluorescence in situ hybridization identified a Y chromosome in the infiltrated mononuclear cells. Surveillance cultures from conjunctival swabs were negative. Thus, we diagnosed these ocular manifestations as an ocular involvement of acute GVHD.

Original languageEnglish
Pages (from-to)332-334
Number of pages3
JournalInternational journal of hematology
Volume75
Issue number3
DOIs
Publication statusPublished - Apr 1 2002

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this