Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation

Takashi Saito, Katsuji Shinagawa, Katsuto Takenaka, Keitaro Matsuo, Tadashi Yoshino, Katsuyuki Kiura, Kenji Niiya, Mine Harada

Research output: Contribution to journalArticle

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Abstract

A 26-year-old woman with acute myeloid leukemia underwent allogeneic peripheral blood stem cell transplantation from an HLA-identical brother. Eighteen days after transplantation, the patient developed grade II acute graft-versus-host disease (GVHD) and was treated with corticosteroids. On day 38, the patient complained of eye pain and lacrimation. A slitlamp examination revealed corneal ulcers and pseudomembranous formation in both eyes. Histologic and immunohistochemical examinations of the pseudomembrane disclosed an infiltrate dominated by T cells. A cytogenetic study of the pseudomembrane by fluorescence in situ hybridization identified a Y chromosome in the infiltrated mononuclear cells. Surveillance cultures from conjunctival swabs were negative. Thus, we diagnosed these ocular manifestations as an ocular involvement of acute GVHD.

Original languageEnglish
Pages (from-to)332-334
Number of pages3
JournalInternational Journal of Hematology
Volume75
Issue number3
DOIs
Publication statusPublished - Apr 1 2002

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Eye Manifestations
Peripheral Blood Stem Cell Transplantation
Graft vs Host Disease
Eye Pain
Corneal Ulcer
Y Chromosome
Fluorescence In Situ Hybridization
Acute Myeloid Leukemia
Cytogenetics
Siblings
Adrenal Cortex Hormones
Transplantation
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation. / Saito, Takashi; Shinagawa, Katsuji; Takenaka, Katsuto; Matsuo, Keitaro; Yoshino, Tadashi; Kiura, Katsuyuki; Niiya, Kenji; Harada, Mine.

In: International Journal of Hematology, Vol. 75, No. 3, 01.04.2002, p. 332-334.

Research output: Contribution to journalArticle

Saito, T, Shinagawa, K, Takenaka, K, Matsuo, K, Yoshino, T, Kiura, K, Niiya, K & Harada, M 2002, 'Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation', International Journal of Hematology, vol. 75, no. 3, pp. 332-334. https://doi.org/10.1007/BF02982052
Saito, Takashi ; Shinagawa, Katsuji ; Takenaka, Katsuto ; Matsuo, Keitaro ; Yoshino, Tadashi ; Kiura, Katsuyuki ; Niiya, Kenji ; Harada, Mine. / Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation. In: International Journal of Hematology. 2002 ; Vol. 75, No. 3. pp. 332-334.
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