Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation

Takashi Saito, Katsuji Shinagawa, Katsuto Takenaka, Keitaro Matsuo, Tadashi Yoshino, Katsuyuki Kiura, Kenji Niiya, Mine Harada

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34 Citations (Scopus)


A 26-year-old woman with acute myeloid leukemia underwent allogeneic peripheral blood stem cell transplantation from an HLA-identical brother. Eighteen days after transplantation, the patient developed grade II acute graft-versus-host disease (GVHD) and was treated with corticosteroids. On day 38, the patient complained of eye pain and lacrimation. A slitlamp examination revealed corneal ulcers and pseudomembranous formation in both eyes. Histologic and immunohistochemical examinations of the pseudomembrane disclosed an infiltrate dominated by T cells. A cytogenetic study of the pseudomembrane by fluorescence in situ hybridization identified a Y chromosome in the infiltrated mononuclear cells. Surveillance cultures from conjunctival swabs were negative. Thus, we diagnosed these ocular manifestations as an ocular involvement of acute GVHD.

Original languageEnglish
Pages (from-to)332-334
Number of pages3
JournalInternational journal of hematology
Issue number3
Publication statusPublished - Apr 1 2002


All Science Journal Classification (ASJC) codes

  • Hematology

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