[Ocular surface squamous neoplasia: analysis of 34 cases].

Mika Tanabe, Hiroshi Yoshikawa, Yoko Onishi, Ri ichiro Kohno, Tatsuro Ishibashi

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Abstract

To evaluate location, treatment and clinical course in cases of ocular surface squamous neoplasia (OSSN). Thirty-four cases with OSSN [conjunctival intraepithelial neoplasia (CIN) 17 cases; squamous cell carcinoma (SCC) 17 cases] treated in Kyushu University hospital from 2000 to 2011 were retrospectively studied. Lesions of CIN were observed in the conjunctiva bulbar in sixteen cases (16/17), and in eleven of those, the lesions were seen in the nasal part (nasal : lateral = 11 : 6). The lesions of eight SCC cases (8/17) were observed in the conjunctiva bulbar, of seven cases (7/17) were observed in the conjunctiva palpebral, and of two cases (2/17) in the fornical conjunctiva. Significantly far more cases of SCC in the conjunctiva bulbar were seen in the nasal part compared to the lateral part (nasal : lateral = 7 : 1). Most SCC lesions in the conjunctiva palpebral and fornix were observed in the upper eyelid (upper : lower = 6 : 3). CIN were treated by excision in nine cases (9/17), excision after topical chemotherapy in three cases (3/ 17), and topical chemotherapy in 5 cases (5/17). Nine SCC patients were treated by excision (9/17), four by excision after topical chemotherapy (4/17), and four by radiotherapy (4/17). Three cases of CIN and one case of SCC had recurrence and needed further treatment. The use of preoperative chemotherapy and radiotherapy for OSSN patients seems useful for a good outcome.

Original languageEnglish
Pages (from-to)425-432
Number of pages8
JournalNippon Ganka Gakkai zasshi
Volume118
Issue number5
Publication statusPublished - May 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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