Odorant receptor gene choice and axonal projection in the mouse olfactory system

T. Imai, H. Sakano

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Abstract

In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses a single type of odorant receptor (OR) out of approximately 1,000 in a monoallelic manner. Furthermore, OSNs expressing the same OR converge their axons to a specific set of glomeruli on the olfactory bulb. These two basic principles are fundamental to the peripheral olfactory system, and are regulated by the expressed OR protein itself. Singular OR gene choice is ensured by the combination of stochastic enhancer-promoter interaction and negative-feedback regulation by OR proteins. In the axonal projection, OR-derived cyclic AMP signals and neuronal activity determine the expression levels of axon guidance/ sorting molecules, and thereby direct glomerular positioning and axon sorting.

Original languageEnglish
Title of host publicationChemosensory Systems in Mammals, Fishes, and Insects
EditorsWolfgang Meyerhof, Sigrun Korsching
Pages57-75
Number of pages19
DOIs
Publication statusPublished - May 11 2009
Externally publishedYes

Publication series

NameResults and Problems in Cell Differentiation
Volume47
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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