Oesophageal cancer composed of mixed histological types

Hiroyuki Kuwano, Noriaki Sadanaga, Masayuki Watanabe, Mitsuhiro Yasuda, Tadahiro Nozoe, Keizo Sugimachi

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Abstract

Glandular or adenoid cystic differentiation and sarcomatous features are sometimes encountered in oesophageal cancer and such histological variants often coexist with ordinary squamous cell carcinoma. So far no serial evaluation of such mixed histological types of oesophageal cancer has ever been performed, we therefore clinicopathologically investigated such cases while an immunohistochemical study of the p53 protein was also done on four available cases in order to discuss the histogenesis of these tumours. Among the 600 patients with surgically resected oesophageal cancer, seven cases mere found to have a mixture of histological variants with ordinary SCC (squamous cell carcinoma) (adenocarcinoma 1, adenoid cystic cancer 3, sarcomatous component 2, basaloid cystic cancer and sarcomatous component 1). All but one case had an elevated type tumour while the predominant components of protrusion mere not SCC but variant histological types. Six tumours mere restricted to the submucosal layer. An immunohistochemical study of the p53 protein revealed that two of four cases mere positive in both the SCC and variant patterns. Mixed histological types of oesophageal cancer composed of SCC and other variants often occur and thus the carcinogenesis of both histological types are considered to be aspects of the same mechanism.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume22
Issue number3
DOIs
Publication statusPublished - Jan 1 1996

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Esophageal Neoplasms
Squamous Cell Carcinoma
Adenoids
Neoplasms
Carcinogenesis
Proteins
Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Kuwano, H., Sadanaga, N., Watanabe, M., Yasuda, M., Nozoe, T., & Sugimachi, K. (1996). Oesophageal cancer composed of mixed histological types. European Journal of Surgical Oncology, 22(3), 225-231. https://doi.org/10.1016/S0748-7983(96)80007-2

Oesophageal cancer composed of mixed histological types. / Kuwano, Hiroyuki; Sadanaga, Noriaki; Watanabe, Masayuki; Yasuda, Mitsuhiro; Nozoe, Tadahiro; Sugimachi, Keizo.

In: European Journal of Surgical Oncology, Vol. 22, No. 3, 01.01.1996, p. 225-231.

Research output: Contribution to journalArticle

Kuwano, H, Sadanaga, N, Watanabe, M, Yasuda, M, Nozoe, T & Sugimachi, K 1996, 'Oesophageal cancer composed of mixed histological types', European Journal of Surgical Oncology, vol. 22, no. 3, pp. 225-231. https://doi.org/10.1016/S0748-7983(96)80007-2
Kuwano H, Sadanaga N, Watanabe M, Yasuda M, Nozoe T, Sugimachi K. Oesophageal cancer composed of mixed histological types. European Journal of Surgical Oncology. 1996 Jan 1;22(3):225-231. https://doi.org/10.1016/S0748-7983(96)80007-2
Kuwano, Hiroyuki ; Sadanaga, Noriaki ; Watanabe, Masayuki ; Yasuda, Mitsuhiro ; Nozoe, Tadahiro ; Sugimachi, Keizo. / Oesophageal cancer composed of mixed histological types. In: European Journal of Surgical Oncology. 1996 ; Vol. 22, No. 3. pp. 225-231.
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