TY - JOUR
T1 - OEstrogènes et neurogenèse
T2 - de nouvelles fonctions pour une vieille hormone. Leçons tirèes du poisson zèbre
AU - Kah, Olivier
AU - Pellegrini, Elisabeth
AU - Mouriec, Karen
AU - Diotel, Nicolas
AU - Anglade, Isabelle
AU - Vaillant, Colette
AU - Thieulant, Marie Lise
AU - Tong, Sok Keng
AU - Brion, François
AU - Chung, Bon Chu
AU - Pakdel, Farzad
PY - 2009
Y1 - 2009
N2 - In contrast to other vertebrates, in which the adult brain shows limited adult neurogenesis, teleost fish exhibit an unparalleled capacity to generate new neurons as adults, suggesting that their brains present a highly permissive environment for the maintenance and proliferation of adult progenitors. Here, we examine the hypothesis that one of the factors permitting establishment of this favourable environment is estradiol. Indeed, recent data showed that radial glial cells strongly expressed one of two aromatase duplicated genes. Aromatase is the estrogen-synthesizing enzyme and this observation is of great interest, given that radial glial cells are progenitor cells capable of generating new neurons. Given the well documented roles of estrogens on cell fate, and notably on cell proliferation, these data suggest that estradiol could be involved in maintaining and/or activating these progenitors. Examination of recent data in birds and mammals suggests that the situation in fish could well be an exaggeration of a more general mechanism implicating estrogens in neurogenesis. Indeed, there is accumulating evidence that estrogens are involved in embryonic, adult or reparative neurogenesis in other vertebrates, notably in mammals.
AB - In contrast to other vertebrates, in which the adult brain shows limited adult neurogenesis, teleost fish exhibit an unparalleled capacity to generate new neurons as adults, suggesting that their brains present a highly permissive environment for the maintenance and proliferation of adult progenitors. Here, we examine the hypothesis that one of the factors permitting establishment of this favourable environment is estradiol. Indeed, recent data showed that radial glial cells strongly expressed one of two aromatase duplicated genes. Aromatase is the estrogen-synthesizing enzyme and this observation is of great interest, given that radial glial cells are progenitor cells capable of generating new neurons. Given the well documented roles of estrogens on cell fate, and notably on cell proliferation, these data suggest that estradiol could be involved in maintaining and/or activating these progenitors. Examination of recent data in birds and mammals suggests that the situation in fish could well be an exaggeration of a more general mechanism implicating estrogens in neurogenesis. Indeed, there is accumulating evidence that estrogens are involved in embryonic, adult or reparative neurogenesis in other vertebrates, notably in mammals.
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UR - http://www.scopus.com/inward/citedby.url?scp=77952317825&partnerID=8YFLogxK
U2 - 10.1051/jbio:2009007
DO - 10.1051/jbio:2009007
M3 - 学術誌
C2 - 19358809
AN - SCOPUS:77952317825
VL - 203
SP - 29
EP - 38
JO - Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales
JF - Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales
SN - 2105-0678
IS - 1
ER -