OEstrogènes et neurogenèse: de nouvelles fonctions pour une vieille hormone. Leçons tirèes du poisson zèbre

Translated title of the contribution: Oestrogens and neurogenesis: New functions for an old hormone. Lessons from the zebrafish

Olivier Kah, Elisabeth Pellegrini, Karen Mouriec, Nicolas Diotel, Isabelle Anglade, Colette Vaillant, Marie Lise Thieulant, Sok Keng Tong, François Brion, Bon Chu Chung, Farzad Pakdel

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In contrast to other vertebrates, in which the adult brain shows limited adult neurogenesis, teleost fish exhibit an unparalleled capacity to generate new neurons as adults, suggesting that their brains present a highly permissive environment for the maintenance and proliferation of adult progenitors. Here, we examine the hypothesis that one of the factors permitting establishment of this favourable environment is estradiol. Indeed, recent data showed that radial glial cells strongly expressed one of two aromatase duplicated genes. Aromatase is the estrogen-synthesizing enzyme and this observation is of great interest, given that radial glial cells are progenitor cells capable of generating new neurons. Given the well documented roles of estrogens on cell fate, and notably on cell proliferation, these data suggest that estradiol could be involved in maintaining and/or activating these progenitors. Examination of recent data in birds and mammals suggests that the situation in fish could well be an exaggeration of a more general mechanism implicating estrogens in neurogenesis. Indeed, there is accumulating evidence that estrogens are involved in embryonic, adult or reparative neurogenesis in other vertebrates, notably in mammals.

Original languageFrench
Pages (from-to)29-38
Number of pages10
JournalJournal de la Societe de Biologie
Volume203
Issue number1
DOIs
Publication statusPublished - Dec 1 2009

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All Science Journal Classification (ASJC) codes

  • Ageing
  • Cell Biology

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