Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption

Sakumi Kunihiko, Yohei Tominaga, Masato Furuichi, Ping Xu, Teruhisa Tsuzuki, Mutsuo Sekiguchi, Yusaku Nakabeppu

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA. We found that lung adenoma/carcinoma spontaneously developed in Ogg1 knockout mice ∼1.5 years after birth in which 8-oxoG was found to accumulate in their genomes. The mean number of tumors/mouse was 0.71 for the Ogg1 knockout mice, which was five times higher than that observed in wild-type mice (0.14). Although the accumulation of 8-oxoG was also confirmed in the Ogg1, Mth1 double knockout mice, we found no tumor in the lungs of these mice. This observation suggests that Mthl gene disruption resulted in a suppression of the tumorigenesis caused by an Ogg1 deficiency.

Original languageEnglish
Pages (from-to)902-905
Number of pages4
JournalCancer Research
Volume63
Issue number5
Publication statusPublished - Mar 1 2003

Fingerprint

Knockout Mice
Carcinogenesis
Lung
Genes
Adenoma
Neoplasms
Parturition
Genome
Carcinoma
DNA
Enzymes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. / Kunihiko, Sakumi; Tominaga, Yohei; Furuichi, Masato; Xu, Ping; Tsuzuki, Teruhisa; Sekiguchi, Mutsuo; Nakabeppu, Yusaku.

In: Cancer Research, Vol. 63, No. 5, 01.03.2003, p. 902-905.

Research output: Contribution to journalArticle

Kunihiko, Sakumi ; Tominaga, Yohei ; Furuichi, Masato ; Xu, Ping ; Tsuzuki, Teruhisa ; Sekiguchi, Mutsuo ; Nakabeppu, Yusaku. / Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. In: Cancer Research. 2003 ; Vol. 63, No. 5. pp. 902-905.
@article{b595e9942779426bb5c9cd13e937ae6e,
title = "Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption",
abstract = "Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA. We found that lung adenoma/carcinoma spontaneously developed in Ogg1 knockout mice ∼1.5 years after birth in which 8-oxoG was found to accumulate in their genomes. The mean number of tumors/mouse was 0.71 for the Ogg1 knockout mice, which was five times higher than that observed in wild-type mice (0.14). Although the accumulation of 8-oxoG was also confirmed in the Ogg1, Mth1 double knockout mice, we found no tumor in the lungs of these mice. This observation suggests that Mthl gene disruption resulted in a suppression of the tumorigenesis caused by an Ogg1 deficiency.",
author = "Sakumi Kunihiko and Yohei Tominaga and Masato Furuichi and Ping Xu and Teruhisa Tsuzuki and Mutsuo Sekiguchi and Yusaku Nakabeppu",
year = "2003",
month = "3",
day = "1",
language = "English",
volume = "63",
pages = "902--905",
journal = "Journal of Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

TY - JOUR

T1 - Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption

AU - Kunihiko, Sakumi

AU - Tominaga, Yohei

AU - Furuichi, Masato

AU - Xu, Ping

AU - Tsuzuki, Teruhisa

AU - Sekiguchi, Mutsuo

AU - Nakabeppu, Yusaku

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA. We found that lung adenoma/carcinoma spontaneously developed in Ogg1 knockout mice ∼1.5 years after birth in which 8-oxoG was found to accumulate in their genomes. The mean number of tumors/mouse was 0.71 for the Ogg1 knockout mice, which was five times higher than that observed in wild-type mice (0.14). Although the accumulation of 8-oxoG was also confirmed in the Ogg1, Mth1 double knockout mice, we found no tumor in the lungs of these mice. This observation suggests that Mthl gene disruption resulted in a suppression of the tumorigenesis caused by an Ogg1 deficiency.

AB - Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA. We found that lung adenoma/carcinoma spontaneously developed in Ogg1 knockout mice ∼1.5 years after birth in which 8-oxoG was found to accumulate in their genomes. The mean number of tumors/mouse was 0.71 for the Ogg1 knockout mice, which was five times higher than that observed in wild-type mice (0.14). Although the accumulation of 8-oxoG was also confirmed in the Ogg1, Mth1 double knockout mice, we found no tumor in the lungs of these mice. This observation suggests that Mthl gene disruption resulted in a suppression of the tumorigenesis caused by an Ogg1 deficiency.

UR - http://www.scopus.com/inward/record.url?scp=0037374556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037374556&partnerID=8YFLogxK

M3 - Article

VL - 63

SP - 902

EP - 905

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

IS - 5

ER -