Oleanane-type glycosides from the roots of Weigela florida “rumba” and evaluation of their antibody recognition

Anne Sophie Champy-Tixier, Anne Claire Mitaine-Offer, Feliciana Real Fernández, Tomofumi Miyamoto, Chiaki Tanaka, Anna Maria Papini, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticle

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Abstract

Three triterpene glycosides were isolated from the roots of Weigela florida “rumba” (Bunge) A. DC.: two previously undescribed 3-O-β-D-xylopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-xylopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid (1) and 3-O-β-D-xylopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-β-D-xylopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid (2), and one isolated for the first time from a natural source 3-O-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid (3). Their structures were elucidated mainly by 2D NMR spectroscopic analysis (COSY, TOCSY, NOESY, HSQC, HMBC) and mass spectrometry. Compounds 2 and 3 were further evaluated as antigens in enzyme-linked immunosorbent assay (ELISA) to recognize IgM antibodies in multiple sclerosis (MS) patients’ sera.

Original languageEnglish
Pages (from-to)198-203
Number of pages6
JournalFitoterapia
Volume128
DOIs
Publication statusPublished - Jul 1 2018

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Glycosides
Acids
Antibodies
Triterpenes
Multiple Sclerosis
Immunoglobulin M
Mass Spectrometry
Enzyme-Linked Immunosorbent Assay
Antigens
Serum
oleanane

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Champy-Tixier, A. S., Mitaine-Offer, A. C., Real Fernández, F., Miyamoto, T., Tanaka, C., Papini, A. M., & Lacaille-Dubois, M. A. (2018). Oleanane-type glycosides from the roots of Weigela florida “rumba” and evaluation of their antibody recognition. Fitoterapia, 128, 198-203. https://doi.org/10.1016/j.fitote.2018.04.017

Oleanane-type glycosides from the roots of Weigela florida “rumba” and evaluation of their antibody recognition. / Champy-Tixier, Anne Sophie; Mitaine-Offer, Anne Claire; Real Fernández, Feliciana; Miyamoto, Tomofumi; Tanaka, Chiaki; Papini, Anna Maria; Lacaille-Dubois, Marie Aleth.

In: Fitoterapia, Vol. 128, 01.07.2018, p. 198-203.

Research output: Contribution to journalArticle

Champy-Tixier, Anne Sophie ; Mitaine-Offer, Anne Claire ; Real Fernández, Feliciana ; Miyamoto, Tomofumi ; Tanaka, Chiaki ; Papini, Anna Maria ; Lacaille-Dubois, Marie Aleth. / Oleanane-type glycosides from the roots of Weigela florida “rumba” and evaluation of their antibody recognition. In: Fitoterapia. 2018 ; Vol. 128. pp. 198-203.
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