Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans

Koji Yamada, Takaaki Hirotsu, Masahiro Matsuki, Rebecca A. Butcher, Masahiro Tomioka, Takeshi Ishihara, Jon Clardy, Hirofumi Kunitomo, Yuichi Iino

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Population density - dependent dispersal is a well-characterized strategy of animal behavior in which dispersal rate increases when population density is higher. Caenorhabditis elegans shows positive chemotaxis to a set of odorants, but the chemotaxis switches from attraction to dispersal after prolonged exposure to the odorants. We show here that this plasticity of olfactory behavior is dependent on population density and that this regulation is mediated by pheromonal signaling. We show that a peptide, suppressor of NEP-2 (SNET-1), negatively regulates olfactory plasticity and that its expression is down-regulated by the pheromone. NEP-2, a homolog of the extracellular peptidase neprilysin, antagonizes SNET-1, and this function is essential for olfactory plasticity. These results suggest that population density information is transmitted through the external pheromone and endogenous peptide signaling to modulate chemotactic behavior.

Original languageEnglish
Pages (from-to)1647-1650
Number of pages4
JournalScience
Volume329
Issue number5999
DOIs
Publication statusPublished - Sep 24 2010

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Caenorhabditis elegans
Population Density
Pheromones
Chemotaxis
Neprilysin
Animal Behavior
Peptides
Peptide Hydrolases
Odorants

All Science Journal Classification (ASJC) codes

  • General

Cite this

Yamada, K., Hirotsu, T., Matsuki, M., Butcher, R. A., Tomioka, M., Ishihara, T., ... Iino, Y. (2010). Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. Science, 329(5999), 1647-1650. https://doi.org/10.1126/science.1192020

Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. / Yamada, Koji; Hirotsu, Takaaki; Matsuki, Masahiro; Butcher, Rebecca A.; Tomioka, Masahiro; Ishihara, Takeshi; Clardy, Jon; Kunitomo, Hirofumi; Iino, Yuichi.

In: Science, Vol. 329, No. 5999, 24.09.2010, p. 1647-1650.

Research output: Contribution to journalArticle

Yamada, K, Hirotsu, T, Matsuki, M, Butcher, RA, Tomioka, M, Ishihara, T, Clardy, J, Kunitomo, H & Iino, Y 2010, 'Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans', Science, vol. 329, no. 5999, pp. 1647-1650. https://doi.org/10.1126/science.1192020
Yamada K, Hirotsu T, Matsuki M, Butcher RA, Tomioka M, Ishihara T et al. Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. Science. 2010 Sep 24;329(5999):1647-1650. https://doi.org/10.1126/science.1192020
Yamada, Koji ; Hirotsu, Takaaki ; Matsuki, Masahiro ; Butcher, Rebecca A. ; Tomioka, Masahiro ; Ishihara, Takeshi ; Clardy, Jon ; Kunitomo, Hirofumi ; Iino, Yuichi. / Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. In: Science. 2010 ; Vol. 329, No. 5999. pp. 1647-1650.
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