Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor

Yuhui Huang; Mami Sumida; Motofumi Kumazoe; Kaori Sugihara; Yumi Suemasu; Shuhei Yamada; Shuya Yamashita; Jyunichi Miyakawa; Takashi Takahashi; Hiroshi Tanaka; Yoshinori Fujimura; Hirofumi Tachibana

doi:10.1039/c6cc09504f

Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor

Yuhui Huang, Mami Sumida, Motofumi Kumazoe, Kaori Sugihara, Yumi Suemasu, Shuhei Yamada, Shuya Yamashita, Jyunichi Miyakawa, Takashi Takahashi, Hiroshi Tanaka, Yoshinori Fujimura, Hirofumi Tachibana

Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Green tea polyphenol (−)-epigallocatechin-3-O-gallate (EGCG) has been attributed to the activation of its cell surface sensing receptor 67 kDa laminin receptor (67LR). However, the action of EGCG to activate 67LR remains unknown. Here we show that EGCG undergoes oligomer formation on its surface receptor 67LR.

Original language	English
Pages (from-to)	1941-1944
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	12
DOIs	https://doi.org/10.1039/c6cc09504f
Publication status	Published - 2017

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c6cc09504f

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Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor. / Huang, Yuhui; Sumida, Mami; Kumazoe, Motofumi; Sugihara, Kaori; Suemasu, Yumi; Yamada, Shuhei; Yamashita, Shuya; Miyakawa, Jyunichi; Takahashi, Takashi; Tanaka, Hiroshi; Fujimura, Yoshinori ; Tachibana, Hirofumi.

In: Chemical Communications, Vol. 53, No. 12, 2017, p. 1941-1944.

Research output: Contribution to journal › Article › peer-review

Huang, Yuhui ; Sumida, Mami ; Kumazoe, Motofumi ; Sugihara, Kaori ; Suemasu, Yumi ; Yamada, Shuhei ; Yamashita, Shuya ; Miyakawa, Jyunichi ; Takahashi, Takashi ; Tanaka, Hiroshi ; Fujimura, Yoshinori ; Tachibana, Hirofumi. / Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor. In: Chemical Communications. 2017 ; Vol. 53, No. 12. pp. 1941-1944.

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title = "Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor",

abstract = "Green tea polyphenol (−)-epigallocatechin-3-O-gallate (EGCG) has been attributed to the activation of its cell surface sensing receptor 67 kDa laminin receptor (67LR). However, the action of EGCG to activate 67LR remains unknown. Here we show that EGCG undergoes oligomer formation on its surface receptor 67LR.",

author = "Yuhui Huang and Mami Sumida and Motofumi Kumazoe and Kaori Sugihara and Yumi Suemasu and Shuhei Yamada and Shuya Yamashita and Jyunichi Miyakawa and Takashi Takahashi and Hiroshi Tanaka and Yoshinori Fujimura and Hirofumi Tachibana",

note = "Funding Information: Financial support of this work from the National Natural Science Foundation of JSPS KAKENHI grants 22228002 and 15H02448 to H. Tachibana is gratefully acknowledged. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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AU - Huang, Yuhui

AU - Sumida, Mami

AU - Kumazoe, Motofumi

AU - Sugihara, Kaori

AU - Suemasu, Yumi

AU - Yamada, Shuhei

AU - Yamashita, Shuya

AU - Miyakawa, Jyunichi

AU - Takahashi, Takashi

AU - Tanaka, Hiroshi

AU - Fujimura, Yoshinori

AU - Tachibana, Hirofumi

N1 - Funding Information: Financial support of this work from the National Natural Science Foundation of JSPS KAKENHI grants 22228002 and 15H02448 to H. Tachibana is gratefully acknowledged. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - Green tea polyphenol (−)-epigallocatechin-3-O-gallate (EGCG) has been attributed to the activation of its cell surface sensing receptor 67 kDa laminin receptor (67LR). However, the action of EGCG to activate 67LR remains unknown. Here we show that EGCG undergoes oligomer formation on its surface receptor 67LR.

AB - Green tea polyphenol (−)-epigallocatechin-3-O-gallate (EGCG) has been attributed to the activation of its cell surface sensing receptor 67 kDa laminin receptor (67LR). However, the action of EGCG to activate 67LR remains unknown. Here we show that EGCG undergoes oligomer formation on its surface receptor 67LR.

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Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor

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