Abstract
Oligonucleotides attaching a reactive molecule may cause irreversible change to the target sequence at the reactive site. Inhibition of transcription, site-directed mutagenesis (or site-directed manipulation of genes) at the specific site has been proposed as a new tool of biotechnology with the use of a triplex-forming oligonucleotide. Thus, the oligonucleotides are regarded as a tool for intracellular DOS of useful reactive molecules. This review deals with development of a new alkylating group with high selectivity toward cytosine as well as new non-natural base analogs for the formation of stable non-natural triplexes.
Original language | English |
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Pages (from-to) | 478-485 |
Number of pages | 8 |
Journal | Drug Delivery System |
Volume | 17 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2002 |
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science