Abstract
Oligonucleotides attaching a reactive molecule may cause irreversible change to the target sequence at the reactive site. Inhibition of transcription, site-directed mutagenesis (or site-directed manipulation of genes) at the specific site has been proposed as a new tool of biotechnology with the use of a triplex-forming oligonucleotide. Thus, the oligonucleotides are regarded as a tool for intracellular DOS of useful reactive molecules. This review deals with development of a new alkylating group with high selectivity toward cytosine as well as new non-natural base analogs for the formation of stable non-natural triplexes.
| Original language | English |
|---|---|
| Pages (from-to) | 478-485 |
| Number of pages | 8 |
| Journal | Drug Delivery System |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jan 1 2002 |
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All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
Cite this
Oligonucleotides as a tool for intracellular DDS. / Sasaki, Shigeki.
In: Drug Delivery System, Vol. 17, No. 6, 01.01.2002, p. 478-485.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Oligonucleotides as a tool for intracellular DDS
AU - Sasaki, Shigeki
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Oligonucleotides attaching a reactive molecule may cause irreversible change to the target sequence at the reactive site. Inhibition of transcription, site-directed mutagenesis (or site-directed manipulation of genes) at the specific site has been proposed as a new tool of biotechnology with the use of a triplex-forming oligonucleotide. Thus, the oligonucleotides are regarded as a tool for intracellular DOS of useful reactive molecules. This review deals with development of a new alkylating group with high selectivity toward cytosine as well as new non-natural base analogs for the formation of stable non-natural triplexes.
AB - Oligonucleotides attaching a reactive molecule may cause irreversible change to the target sequence at the reactive site. Inhibition of transcription, site-directed mutagenesis (or site-directed manipulation of genes) at the specific site has been proposed as a new tool of biotechnology with the use of a triplex-forming oligonucleotide. Thus, the oligonucleotides are regarded as a tool for intracellular DOS of useful reactive molecules. This review deals with development of a new alkylating group with high selectivity toward cytosine as well as new non-natural base analogs for the formation of stable non-natural triplexes.
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UR - http://www.scopus.com/inward/citedby.url?scp=85024451811&partnerID=8YFLogxK
U2 - 10.2745/dds.17.478
DO - 10.2745/dds.17.478
M3 - Article
AN - SCOPUS:85024451811
VL - 17
SP - 478
EP - 485
JO - Drug Delivery System
JF - Drug Delivery System
SN - 0913-5006
IS - 6
ER -