Oligonuleotide delivery with dendritic poly(L-lysine) for treatments of the liver disorders

K. Watanabe, M. Harada-Shiba, A. Suzuki, Y. Higuchi, S. Kawakami, M. Hashida, R. Gokuden, R. Kurihara, Y. Sugao, Takeshi Mori, Yoshiki Katayama, T. Niidome

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A cationic peptide dendrier, dendritic poly(L-lysine), forms complexes with oligonucleotides and can deliver them to liver after intravenous injection. Here, we tried to deliver apolipoprotein B-specific siRNA for the treatment of hypercholesterolemia and NFκB decoy for the hepatitis treatment. Significant therapeutic effects in those disease model mice were observed after intravenous injection of the oligonucleotides complexes with dendritic poly(L-lysine).

Original languageEnglish
Title of host publicationNanobiotechnology and Nanobiophotonics - Opportunities and Challenges
Number of pages6
Publication statusPublished - Dec 1 2010
Event2009 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 29 2009Dec 3 2009

Publication series

NameMaterials Research Society Symposium Proceedings
ISSN (Print)0272-9172


Conference2009 MRS Fall Meeting
CountryUnited States
CityBoston, MA

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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