Oligonuleotide delivery with dendritic poly(L-lysine) for treatments of the liver disorders

K. Watanabe, M. Harada-Shiba, A. Suzuki, Y. Higuchi, S. Kawakami, M. Hashida, R. Gokuden, R. Kurihara, Y. Sugao, Takeshi Mori, Yoshiki Katayama, T. Niidome

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    A cationic peptide dendrier, dendritic poly(L-lysine), forms complexes with oligonucleotides and can deliver them to liver after intravenous injection. Here, we tried to deliver apolipoprotein B-specific siRNA for the treatment of hypercholesterolemia and NFκB decoy for the hepatitis treatment. Significant therapeutic effects in those disease model mice were observed after intravenous injection of the oligonucleotides complexes with dendritic poly(L-lysine).

    Original languageEnglish
    Title of host publicationNanobiotechnology and Nanobiophotonics - Opportunities and Challenges
    Pages12-17
    Number of pages6
    Publication statusPublished - Dec 1 2010
    Event2009 MRS Fall Meeting - Boston, MA, United States
    Duration: Nov 29 2009Dec 3 2009

    Publication series

    NameMaterials Research Society Symposium Proceedings
    Volume1237
    ISSN (Print)0272-9172

    Conference

    Conference2009 MRS Fall Meeting
    Country/TerritoryUnited States
    CityBoston, MA
    Period11/29/0912/3/09

    All Science Journal Classification (ASJC) codes

    • Materials Science(all)
    • Condensed Matter Physics
    • Mechanics of Materials
    • Mechanical Engineering

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