TY - JOUR
T1 - Omnidirectional actuation of magnetically driven microtool for cutting of oocyte in a chip
AU - Inomata, Naoki
AU - Mizunuma, Takehito
AU - Yamanishi, Yoko
AU - Arai, Fumihito
N1 - Funding Information:
Manuscript received May 31, 2010; revised November 4, 2010; accepted November 7, 2010. Date of publication January 13, 2011; date of current version April 1, 2011. This work was supported in part by the Research and Development Program for New Bio-industry Initiatives and in part by the Development of Systems and Technology for Advanced Measurement and Analysis, Japanese Science and Technology Agency. Subject Editor C.-J. Kim.
PY - 2011/4
Y1 - 2011/4
N2 - In this paper, we developed and fabricated a magnetically driven microtool (MMT) and installed it on a microfluidic chip for use in the enucleation of oocytes. The fabricated tool is much smaller than a conventional mechanical micromanipulator used for cell manipulation. We succeeded in driving this MMT in two degrees of freedomin the X - and Y -directions. The MMT works on the principle of noncontact actuation by magnetic force; therefore, the microfluidic-chip part is fully disposable and inexpensive. The MMT consists of a polymer part with a controllable attitude and a rigid metal (Ni) part with good magnetic properties, which are useful for cutting oocytes. We analytically evaluated that the structure for easy attitude control of the polymer part is a four-leg-type configuration. Based on the novel and original design, the MMT and microfluidic chip were fabricated by photolithography. The MMT could generate a force of 3 mN, which is sufficient to cut an oocyte into half. We successfully demonstrated the cutting of an oocyte on a microfluidic chip by using the MMT.
AB - In this paper, we developed and fabricated a magnetically driven microtool (MMT) and installed it on a microfluidic chip for use in the enucleation of oocytes. The fabricated tool is much smaller than a conventional mechanical micromanipulator used for cell manipulation. We succeeded in driving this MMT in two degrees of freedomin the X - and Y -directions. The MMT works on the principle of noncontact actuation by magnetic force; therefore, the microfluidic-chip part is fully disposable and inexpensive. The MMT consists of a polymer part with a controllable attitude and a rigid metal (Ni) part with good magnetic properties, which are useful for cutting oocytes. We analytically evaluated that the structure for easy attitude control of the polymer part is a four-leg-type configuration. Based on the novel and original design, the MMT and microfluidic chip were fabricated by photolithography. The MMT could generate a force of 3 mN, which is sufficient to cut an oocyte into half. We successfully demonstrated the cutting of an oocyte on a microfluidic chip by using the MMT.
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U2 - 10.1109/JMEMS.2010.2100028
DO - 10.1109/JMEMS.2010.2100028
M3 - Article
AN - SCOPUS:79953763061
VL - 20
SP - 383
EP - 388
JO - Journal of Microelectromechanical Systems
JF - Journal of Microelectromechanical Systems
SN - 1057-7157
IS - 2
M1 - 5686907
ER -