Abstract
In this paper, we developed and fabricated a magnetically driven microtool (MMT) and installed it on a microfluidic chip for use in the enucleation of oocytes. The fabricated tool is much smaller than a conventional mechanical micromanipulator used for cell manipulation. We succeeded in driving this MMT in two degrees of freedomin the X - and Y -directions. The MMT works on the principle of noncontact actuation by magnetic force; therefore, the microfluidic-chip part is fully disposable and inexpensive. The MMT consists of a polymer part with a controllable attitude and a rigid metal (Ni) part with good magnetic properties, which are useful for cutting oocytes. We analytically evaluated that the structure for easy attitude control of the polymer part is a four-leg-type configuration. Based on the novel and original design, the MMT and microfluidic chip were fabricated by photolithography. The MMT could generate a force of 3 mN, which is sufficient to cut an oocyte into half. We successfully demonstrated the cutting of an oocyte on a microfluidic chip by using the MMT.
| Original language | English |
|---|---|
| Article number | 5686907 |
| Pages (from-to) | 383-388 |
| Number of pages | 6 |
| Journal | Journal of Microelectromechanical Systems |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 1 2011 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Mechanical Engineering
- Electrical and Electronic Engineering
Cite this
Omnidirectional actuation of magnetically driven microtool for cutting of oocyte in a chip. / Inomata, Naoki; Mizunuma, Takehito; Yamanishi, Yoko; Arai, Fumihito.
In: Journal of Microelectromechanical Systems, Vol. 20, No. 2, 5686907, 01.04.2011, p. 383-388.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Omnidirectional actuation of magnetically driven microtool for cutting of oocyte in a chip
AU - Inomata, Naoki
AU - Mizunuma, Takehito
AU - Yamanishi, Yoko
AU - Arai, Fumihito
PY - 2011/4/1
Y1 - 2011/4/1
N2 - In this paper, we developed and fabricated a magnetically driven microtool (MMT) and installed it on a microfluidic chip for use in the enucleation of oocytes. The fabricated tool is much smaller than a conventional mechanical micromanipulator used for cell manipulation. We succeeded in driving this MMT in two degrees of freedomin the X - and Y -directions. The MMT works on the principle of noncontact actuation by magnetic force; therefore, the microfluidic-chip part is fully disposable and inexpensive. The MMT consists of a polymer part with a controllable attitude and a rigid metal (Ni) part with good magnetic properties, which are useful for cutting oocytes. We analytically evaluated that the structure for easy attitude control of the polymer part is a four-leg-type configuration. Based on the novel and original design, the MMT and microfluidic chip were fabricated by photolithography. The MMT could generate a force of 3 mN, which is sufficient to cut an oocyte into half. We successfully demonstrated the cutting of an oocyte on a microfluidic chip by using the MMT.
AB - In this paper, we developed and fabricated a magnetically driven microtool (MMT) and installed it on a microfluidic chip for use in the enucleation of oocytes. The fabricated tool is much smaller than a conventional mechanical micromanipulator used for cell manipulation. We succeeded in driving this MMT in two degrees of freedomin the X - and Y -directions. The MMT works on the principle of noncontact actuation by magnetic force; therefore, the microfluidic-chip part is fully disposable and inexpensive. The MMT consists of a polymer part with a controllable attitude and a rigid metal (Ni) part with good magnetic properties, which are useful for cutting oocytes. We analytically evaluated that the structure for easy attitude control of the polymer part is a four-leg-type configuration. Based on the novel and original design, the MMT and microfluidic chip were fabricated by photolithography. The MMT could generate a force of 3 mN, which is sufficient to cut an oocyte into half. We successfully demonstrated the cutting of an oocyte on a microfluidic chip by using the MMT.
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UR - http://www.scopus.com/inward/citedby.url?scp=79953763061&partnerID=8YFLogxK
U2 - 10.1109/JMEMS.2010.2100028
DO - 10.1109/JMEMS.2010.2100028
M3 - Article
AN - SCOPUS:79953763061
VL - 20
SP - 383
EP - 388
JO - Journal of Microelectromechanical Systems
JF - Journal of Microelectromechanical Systems
SN - 1057-7157
IS - 2
M1 - 5686907
ER -