TY - GEN
T1 - On-chip cell separation based on mechanical characteristics
AU - Nakahara, Kou
AU - Sakuma, Shinya
AU - Arai, Fumihito
N1 - Funding Information:
This work is supported by JSPS Grants-in-Aid for Scientific Research Number 15K18003 and 17H04913. REFERENCES [1] 1. Q. Guo et. al., Lab on a chip, vol. 16, pp. 645-654, 2016 [2] 2. K. Ito et. al., Micromachines, vol. 7, pp. 221-234, 2016. CONTACT * K. Nakahara; phone: +81-52-789-5220; nakahara@biorobotics.mech.nagoya-u.ac.jp
Publisher Copyright:
© 17CBMS-0001.
PY - 2020
Y1 - 2020
N2 - We propose an on-chip cell separation method based on mechanical characteristics using the microfluidic chip where a pair of force sensor probes is integrated, as shown in Fig. 1. We utilize the stiffness index of cell for separation. The cells are compressed by the force sensor probes placed at the measurement area of the microfluidic chip, and their stiffness indexes are obtained from the information of reactive force during deformation.. We constructed the system and evaluated it using mouse oocyte. By switching the flow in the microchannel, we achieved the separation based on the index as shown in Fig. 4.
AB - We propose an on-chip cell separation method based on mechanical characteristics using the microfluidic chip where a pair of force sensor probes is integrated, as shown in Fig. 1. We utilize the stiffness index of cell for separation. The cells are compressed by the force sensor probes placed at the measurement area of the microfluidic chip, and their stiffness indexes are obtained from the information of reactive force during deformation.. We constructed the system and evaluated it using mouse oocyte. By switching the flow in the microchannel, we achieved the separation based on the index as shown in Fig. 4.
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M3 - Conference contribution
AN - SCOPUS:85079643129
T3 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
SP - 677
EP - 678
BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PB - Chemical and Biological Microsystems Society
T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Y2 - 22 October 2017 through 26 October 2017
ER -