On-chip cell separation based on mechanical characteristics

Kou Nakahara, Shinya Sakuma, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We propose an on-chip cell separation method based on mechanical characteristics using the microfluidic chip where a pair of force sensor probes is integrated, as shown in Fig. 1. We utilize the stiffness index of cell for separation. The cells are compressed by the force sensor probes placed at the measurement area of the microfluidic chip, and their stiffness indexes are obtained from the information of reactive force during deformation.. We constructed the system and evaluated it using mouse oocyte. By switching the flow in the microchannel, we achieved the separation based on the index as shown in Fig. 4.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages677-678
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2020
Externally publishedYes
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: Oct 22 2017Oct 26 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period10/22/1710/26/17

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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