Oncogenesis by retroviruses: Old and new paradigms

Naoyoshi Maeda, Hung Fan, Yasunobu Yoshikai

    Research output: Contribution to journalReview article

    55 Citations (Scopus)

    Abstract

    Retroviruses are associated with a variety of diseases including an array of malignancies, immunodeficiencies and neurological disorders. In particular, studies of oncogenic retroviruses established fundamental principles of modern molecular cancer biology. Studies of avian Rous sarcoma virus (RSV) led to the discovery of the viral oncogene src, and this was followed by the discovery of other viral oncogenes in retroviruses of mammals including rodents, cats, monkeys and so forth. Studies of the viral oncogenes in turn led to the discovery of cellular proto-oncogenes in the host genome; cellular oncogenes have been shown to be activated in a variety of human cancers, including those with no viral involvement. Oncogenic animal retroviruses can be divided into two groups based on their mechanisms of tumourigenesis, acute transforming retroviruses and nonacute retroviruses. Acute transforming retroviruses are typically replication defective and they induce tumours rapidly due to expression of their viral oncogenes. Nonacute retroviruses are replication competent and they induce tumours with longer latencies, by activating cellular proto-oncogenes in the tumour cells; this results from insertion of proviral DNA in the vicinity of the activated proto-oncogene. More recently, human T-cell leukaemia virus type I (HTLV-I) was discovered as an etiological agent of human cancer (adult T-cell leukaemia [ATL]); this virus also encodes regulatory genes some of which are important for its oncogenic potential. Most recently, the retroviral structural protein Envelope (Env) has been shown to be directly involved in oncogenic transformation for certain retroviruses. Env-induced transformation is a new paradigm for retroviral oncogenesis. In this review, we will summarise research on retrovirus oncogenic transformation over the past 100 years since the first published report of an oncogenic virus with particular attention to Env-induced transformation.

    Original languageEnglish
    Pages (from-to)387-405
    Number of pages19
    JournalReviews in Medical Virology
    Volume18
    Issue number6
    DOIs
    Publication statusPublished - Nov 1 2008

    Fingerprint

    Retroviridae
    Carcinogenesis
    Oncogenes
    Proto-Oncogenes
    Neoplasms
    Avian Sarcoma Viruses
    src Genes
    Rous sarcoma virus
    Adult T Cell Leukemia Lymphoma
    Oncogenic Viruses
    Human T-lymphotropic virus 1
    Regulator Genes
    Nervous System Diseases
    Haplorhini
    Molecular Biology
    Mammals
    Rodentia
    Cats
    Genome
    Viruses

    All Science Journal Classification (ASJC) codes

    • Virology
    • Infectious Diseases

    Cite this

    Oncogenesis by retroviruses : Old and new paradigms. / Maeda, Naoyoshi; Fan, Hung; Yoshikai, Yasunobu.

    In: Reviews in Medical Virology, Vol. 18, No. 6, 01.11.2008, p. 387-405.

    Research output: Contribution to journalReview article

    Maeda, N, Fan, H & Yoshikai, Y 2008, 'Oncogenesis by retroviruses: Old and new paradigms', Reviews in Medical Virology, vol. 18, no. 6, pp. 387-405. https://doi.org/10.1002/rmv.592
    Maeda, Naoyoshi ; Fan, Hung ; Yoshikai, Yasunobu. / Oncogenesis by retroviruses : Old and new paradigms. In: Reviews in Medical Virology. 2008 ; Vol. 18, No. 6. pp. 387-405.
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