One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reaction for magnetic hyperthermia and magnetic resonance imaging

Koichiro Hayashi, Kenji Ono, Hiromi Suzuki, Makoto Sawada, Makoto Moriya, Wataru Sakamoto, Toshinobu Yogo

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Cysteine-modified Fe3O4 nanoparticles (Cys-Fe 3O4 NPs) were synthesized by the one-pot biofunctionalization of allyl-functionalized Fe3O4 NPs (allyl-Fe3O4) with cysteine using the in situ hydrolysis-condensation of iron(III) allylacetylacetonate and the thiol-ene click reaction. The particle size of Fe3O4 in Cys-Fe 3O4 NPs measured by transmission electron microscopy and X-ray diffraction analysis was ∼8 nm. Cys-Fe3O4 NPs were soluble in water and had a hydrodynamic diameter of 22 nm and prolonged stability in water. They were superparamagnetic, which was confirmed by fitting the Langevin equation to the magnetization data, generated heat in an alternating current (AC) magnetic field, and had a specific absorption rate (SAR) of 156 W g-1 at 230 kHz and 100 Oe. In addition, they exhibited a T2-weighted magnetic resonance imaging (MRI) contrast-enhancing effect.

Original languageEnglish
Pages (from-to)3768-3772
Number of pages5
JournalChemistry of Materials
Volume22
Issue number12
DOIs
Publication statusPublished - Jun 22 2010

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Magnetic resonance
Sulfhydryl Compounds
Cysteine
Nanoparticles
Imaging techniques
Water
X ray diffraction analysis
Condensation
Hydrolysis
Magnetization
Hydrodynamics
Iron
Particle size
Magnetic fields
Transmission electron microscopy
Hot Temperature

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

Cite this

One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reaction for magnetic hyperthermia and magnetic resonance imaging. / Hayashi, Koichiro; Ono, Kenji; Suzuki, Hiromi; Sawada, Makoto; Moriya, Makoto; Sakamoto, Wataru; Yogo, Toshinobu.

In: Chemistry of Materials, Vol. 22, No. 12, 22.06.2010, p. 3768-3772.

Research output: Contribution to journalArticle

Hayashi, Koichiro ; Ono, Kenji ; Suzuki, Hiromi ; Sawada, Makoto ; Moriya, Makoto ; Sakamoto, Wataru ; Yogo, Toshinobu. / One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reaction for magnetic hyperthermia and magnetic resonance imaging. In: Chemistry of Materials. 2010 ; Vol. 22, No. 12. pp. 3768-3772.
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AU - Moriya, Makoto

AU - Sakamoto, Wataru

AU - Yogo, Toshinobu

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