One-Pot Catalytic Synthesis of α-Tetrasubstituted Amino Acid Derivatives via in Situ Generation of N-Unsubstituted Ketimines

Yuta Kondo, Yoshinobu Hirazawa, Tetsuya Kadota, Koki Yamada, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima

Research output: Contribution to journalArticlepeer-review

Abstract

A one-pot catalytic synthesis of α-tetrasubstituted amino acid derivatives via in situ generation of N-unsubstituted ketimines is reported. Because of the irreversible formation of N-unsubstituted ketimines, the yields were higher than those generated under the conventional one-pot reaction conditions. This process prevents the need to isolate unstable N-unsubstituted ketimines with alkyl substituents and streamlines the synthesis of highly congested α-amino acid derivatives.

Original languageEnglish
Pages (from-to)6594-6598
Number of pages5
JournalOrganic letters
Volume24
Issue number36
DOIs
Publication statusPublished - Sep 16 2022

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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