@article{fb2db91fb8bd46679411b9c1a8e57bfe,
title = "One-Pot Catalytic Synthesis of α-Tetrasubstituted Amino Acid Derivatives via in Situ Generation of N-Unsubstituted Ketimines",
abstract = "A one-pot catalytic synthesis of α-tetrasubstituted amino acid derivatives via in situ generation of N-unsubstituted ketimines is reported. Because of the irreversible formation of N-unsubstituted ketimines, the yields were higher than those generated under the conventional one-pot reaction conditions. This process prevents the need to isolate unstable N-unsubstituted ketimines with alkyl substituents and streamlines the synthesis of highly congested α-amino acid derivatives.",
author = "Yuta Kondo and Yoshinobu Hirazawa and Tetsuya Kadota and Koki Yamada and Kazuhiro Morisaki and Hiroyuki Morimoto and Takashi Ohshima",
note = "Funding Information: This work was supported by a Grant-in-Aid for Transformative Research Areas (A) Digitalization-Driven Transformative Organic Synthesis (Digi-TOS) (MEXT KAKENHI Grants JP21A204, JP21H05207, and JP21H05208) from MEXT, Grants-in-Aid for Scientific Research (B) (JSPS KAKENHI Grants JP17H03972 and JP21H02607 to T.O.) and (C) (JSPS KAKENHI Grants JP18K06581 and JP21K06477 to H.M.) from JSPS, and Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS) (AMED Grants JP21am0101091 and JP22ama121031) from AMED. H.M. thanks the Takeda Science Foundation, the Fugaku Trust for Medical Research, and the QR Program (Qdai-jump Research Program) 02249 for financial support. Y.K. and K.M. thank JSPS for Research Fellowships for Young Scientists. Y.K. is grateful for the support from the Academic Challenge Program 2018 of Kyushu University. Publisher Copyright: {\textcopyright} 2022 American Chemical Society. All rights reserved.",
year = "2022",
month = sep,
day = "16",
doi = "10.1021/acs.orglett.2c02587",
language = "English",
volume = "24",
pages = "6594--6598",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "36",
}