Abstract
Exploiting exogenous and endogenous stimulus-responsive degradable nanoparticles as drug carriers can improve drug delivery systems (DDSs). The use of hollow nanoparticles may facilitate degradation, and combination of DDS with photodynamic therapy (PDT) and photothermal therapy (PTT) may enhance the anticancer effects of treatments. Here, a one-pot synthetic method is presented for an anticancer drug (doxorubicin [DOX]) and photosensitizer-containing hollow hybrid nanoparticles (HNPs) with a disulfide and siloxane framework formed in response to exogenous (light) and endogenous (intracellular glutathione [GSH]) stimuli. The hollow HNPs emit fluorescence within the near-infrared window and allow for the detection of tumors in vivo by fluorescence imaging. Furthermore, the disulfides within the HNP framework are cleaved by intracellular GSH, deforming the HNPs. Light irradiation facilitates penetration of GSH into the HNP framework and leads to the collapse of the HNPs. As a result, DOX is released from the hollow HNPs. Additionally, the hollow HNPs generate singlet oxygen (1O2) and heat in response to light; thus, fluorescence imaging of tumors combined with trimodal therapy consisting of DDS, PDT, and PTT is feasible, resulting in superior therapeutic efficacy. Thus, this method may have several applications in imaging and therapeutics in the future.
| Original language | English |
|---|---|
| Pages (from-to) | 8613-8622 |
| Number of pages | 10 |
| Journal | Advanced Functional Materials |
| Volume | 26 |
| Issue number | 47 |
| DOIs | |
| Publication status | Published - Dec 20 2016 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Materials Science(all)
- Condensed Matter Physics
Cite this
One-Pot Synthesis of Dual Stimulus-Responsive Degradable Hollow Hybrid Nanoparticles for Image-Guided Trimodal Therapy. / Hayashi, Koichiro; Maruhashi, Takuma; Nakamura, Michihiro; Sakamoto, Wataru; Yogo, Toshinobu.
In: Advanced Functional Materials, Vol. 26, No. 47, 20.12.2016, p. 8613-8622.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - One-Pot Synthesis of Dual Stimulus-Responsive Degradable Hollow Hybrid Nanoparticles for Image-Guided Trimodal Therapy
AU - Hayashi, Koichiro
AU - Maruhashi, Takuma
AU - Nakamura, Michihiro
AU - Sakamoto, Wataru
AU - Yogo, Toshinobu
PY - 2016/12/20
Y1 - 2016/12/20
N2 - Exploiting exogenous and endogenous stimulus-responsive degradable nanoparticles as drug carriers can improve drug delivery systems (DDSs). The use of hollow nanoparticles may facilitate degradation, and combination of DDS with photodynamic therapy (PDT) and photothermal therapy (PTT) may enhance the anticancer effects of treatments. Here, a one-pot synthetic method is presented for an anticancer drug (doxorubicin [DOX]) and photosensitizer-containing hollow hybrid nanoparticles (HNPs) with a disulfide and siloxane framework formed in response to exogenous (light) and endogenous (intracellular glutathione [GSH]) stimuli. The hollow HNPs emit fluorescence within the near-infrared window and allow for the detection of tumors in vivo by fluorescence imaging. Furthermore, the disulfides within the HNP framework are cleaved by intracellular GSH, deforming the HNPs. Light irradiation facilitates penetration of GSH into the HNP framework and leads to the collapse of the HNPs. As a result, DOX is released from the hollow HNPs. Additionally, the hollow HNPs generate singlet oxygen (1O2) and heat in response to light; thus, fluorescence imaging of tumors combined with trimodal therapy consisting of DDS, PDT, and PTT is feasible, resulting in superior therapeutic efficacy. Thus, this method may have several applications in imaging and therapeutics in the future.
AB - Exploiting exogenous and endogenous stimulus-responsive degradable nanoparticles as drug carriers can improve drug delivery systems (DDSs). The use of hollow nanoparticles may facilitate degradation, and combination of DDS with photodynamic therapy (PDT) and photothermal therapy (PTT) may enhance the anticancer effects of treatments. Here, a one-pot synthetic method is presented for an anticancer drug (doxorubicin [DOX]) and photosensitizer-containing hollow hybrid nanoparticles (HNPs) with a disulfide and siloxane framework formed in response to exogenous (light) and endogenous (intracellular glutathione [GSH]) stimuli. The hollow HNPs emit fluorescence within the near-infrared window and allow for the detection of tumors in vivo by fluorescence imaging. Furthermore, the disulfides within the HNP framework are cleaved by intracellular GSH, deforming the HNPs. Light irradiation facilitates penetration of GSH into the HNP framework and leads to the collapse of the HNPs. As a result, DOX is released from the hollow HNPs. Additionally, the hollow HNPs generate singlet oxygen (1O2) and heat in response to light; thus, fluorescence imaging of tumors combined with trimodal therapy consisting of DDS, PDT, and PTT is feasible, resulting in superior therapeutic efficacy. Thus, this method may have several applications in imaging and therapeutics in the future.
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U2 - 10.1002/adfm.201603394
DO - 10.1002/adfm.201603394
M3 - Article
AN - SCOPUS:84996969538
VL - 26
SP - 8613
EP - 8622
JO - Advanced Functional Materials
JF - Advanced Functional Materials
SN - 1616-301X
IS - 47
ER -