One-step preparation of organosiloxane-derived silica particles

Song Chen, Akiyoshi Osaka, Satoshi Hayakawa, Yuki Shirosaki, Akihiro Matsumoto, Eiji Fujii, Koji Kawabata, Kanji Tsuru

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Silica particles and their derivatives with meso-structure attracted much attention, but they were synthesized through complicated multi-step procedure. Considering biomedical application, no surfactants, used in almost all cases above, should be employable due to fear of their toxicity. The present study explored one-step sol-gel preparation of silica particles with biomedical functionalities, starting from Stöber-type systems, and characterized by Transmission Electron Micrograph or 29Si MAS NMR spectroscopy. The Ca-containing particles, derived from the precursor system tetraethoxysilane (TEOS)-H2O-C2H5OH (EtOH)-CaCl 2-NH4OH, consisted of primary particles of - IO nm, and were spherical in shape with the diameter of - 1000 nm, where Ca bridged Si-O- on the opposite particle surface. In contrast, the Ca-free particles were smaller with 400-500 nm in size due to the absence of such bridging effects. In addition, the Ca-containing ones deposited petal-like apatite within one week in Kokubo's simulated body fluid (SBF), which was interpreted in terms of the Ca release from the particles. Amino-modified silica particles were derived from the sol-gel precursor system aminopropyltriethoxysilane (APTES)-TEOS-H 2O-EtOH where APTES behaved not only as the catalyst but also a reactant; i.e., this was a self-catalyzed sol-gel system. Hydrogen bonding among the amino group of APTES on one particle surface and with Si-O- on the other was suggested to work in agglomeration of the primary particles. Bovine serum albumin was covalently fixed on the APTES-silica surface, suggesting their applicability of proteins or other growth factor delivery.

Original languageEnglish
Title of host publicationAdvances in Bioceramics and Porous Ceramics II - A Collection of Papers Presented at the 33rd International Conference on Advanced Ceramics and Composites
Pages3-15
Number of pages13
Volume30
Edition6
Publication statusPublished - 2010
EventAdvances in Bioceramics and Porous Ceramics II - 33rd International Conference on Advanced Ceramics and Composites - Daytona Beach, FL, United States
Duration: Jan 18 2009Jan 23 2009

Other

OtherAdvances in Bioceramics and Porous Ceramics II - 33rd International Conference on Advanced Ceramics and Composites
CountryUnited States
CityDaytona Beach, FL
Period1/18/091/23/09

Fingerprint

Silicon Dioxide
Silica
Sol-gels
Particles (particulate matter)
Apatites
Body fluids
Apatite
Polymers
Bovine Serum Albumin
Surface-Active Agents
Nuclear magnetic resonance spectroscopy
Toxicity
Intercellular Signaling Peptides and Proteins
Hydrogen bonds
Surface active agents
Agglomeration
Derivatives
Proteins
Catalysts
amino-propyl-triethoxysilane

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Materials Chemistry

Cite this

Chen, S., Osaka, A., Hayakawa, S., Shirosaki, Y., Matsumoto, A., Fujii, E., ... Tsuru, K. (2010). One-step preparation of organosiloxane-derived silica particles. In Advances in Bioceramics and Porous Ceramics II - A Collection of Papers Presented at the 33rd International Conference on Advanced Ceramics and Composites (6 ed., Vol. 30, pp. 3-15)

One-step preparation of organosiloxane-derived silica particles. / Chen, Song; Osaka, Akiyoshi; Hayakawa, Satoshi; Shirosaki, Yuki; Matsumoto, Akihiro; Fujii, Eiji; Kawabata, Koji; Tsuru, Kanji.

Advances in Bioceramics and Porous Ceramics II - A Collection of Papers Presented at the 33rd International Conference on Advanced Ceramics and Composites. Vol. 30 6. ed. 2010. p. 3-15.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chen, S, Osaka, A, Hayakawa, S, Shirosaki, Y, Matsumoto, A, Fujii, E, Kawabata, K & Tsuru, K 2010, One-step preparation of organosiloxane-derived silica particles. in Advances in Bioceramics and Porous Ceramics II - A Collection of Papers Presented at the 33rd International Conference on Advanced Ceramics and Composites. 6 edn, vol. 30, pp. 3-15, Advances in Bioceramics and Porous Ceramics II - 33rd International Conference on Advanced Ceramics and Composites, Daytona Beach, FL, United States, 1/18/09.
Chen S, Osaka A, Hayakawa S, Shirosaki Y, Matsumoto A, Fujii E et al. One-step preparation of organosiloxane-derived silica particles. In Advances in Bioceramics and Porous Ceramics II - A Collection of Papers Presented at the 33rd International Conference on Advanced Ceramics and Composites. 6 ed. Vol. 30. 2010. p. 3-15
Chen, Song ; Osaka, Akiyoshi ; Hayakawa, Satoshi ; Shirosaki, Yuki ; Matsumoto, Akihiro ; Fujii, Eiji ; Kawabata, Koji ; Tsuru, Kanji. / One-step preparation of organosiloxane-derived silica particles. Advances in Bioceramics and Porous Ceramics II - A Collection of Papers Presented at the 33rd International Conference on Advanced Ceramics and Composites. Vol. 30 6. ed. 2010. pp. 3-15
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