Onset of spermatogenesis is accelerated by gestational administration of 1,2,3,4,6,7-hexachlorinated naphthalene in male rat offspring

Minoru Omura, Yoshito Masuda, Miyuki Hirata, Akiyo Tanaka, Yuji Makita, Rika Ogata, Naohide Inoue

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We treated pregnant rats with 1 μg/kg body weight/day 1,2,3,4,6,7-hexachlorinated naphthalene (1,2,3,4,6,7-HxCN) on days 14-16 of gestation and examined the effects on the reproductive systems of their male offspring at various phases of sexual maturation. Sperm count in the cauda epididymidis did not change in 1,2,3,4,6,7-HxCN-treated rats on postnatal day 89, the age of sexual maturity, but the sperm count in the cauda epididymidis did increase to approximately 180% of the control value on postnatal day 62. In addition, homogenization-resistant testicular spermatids increased to approximately 160% of the control value on postnatal day 48, and the percent of postmeiotic tubules increased to approximately 190% of the control value on postnatal day 31 in this group. These results indicate that the onset of spermatogenesis was accelerated in the 1,2,3,4,6,7-HxCN rats. Serum concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) had already reached the maximum level on postnatal day 31 in the 1,2,3,4,6,7-HxCN group, suggesting that the onset of LH and FSH secretions from the pituitary gland was also accelerated and that this endocrine disruption was the cause of early onset of spermatogenesis in this group. In the fat of 1,2,3,4,6,7-HxCN-treated dams, 5.75 ± 2.81 ppb 1,2,3,4,6,7-HxCN was detected when offspring were weaned. This concentration was 5-10 times higher than that found in human adipose tissue.

Original languageEnglish
Pages (from-to)539-544
Number of pages6
JournalEnvironmental Health Perspectives
Volume108
Issue number6
DOIs
Publication statusPublished - Jan 1 2000

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Spermatogenesis
Sperm Count
Follicle Stimulating Hormone
Luteinizing Hormone
Sexual Maturation
Spermatids
Pituitary Gland
1,2,3,4,6,7-hexachlorinated naphthalene
Adipose Tissue
Fats
Body Weight
Pregnancy
Serum

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Onset of spermatogenesis is accelerated by gestational administration of 1,2,3,4,6,7-hexachlorinated naphthalene in male rat offspring. / Omura, Minoru; Masuda, Yoshito; Hirata, Miyuki; Tanaka, Akiyo; Makita, Yuji; Ogata, Rika; Inoue, Naohide.

In: Environmental Health Perspectives, Vol. 108, No. 6, 01.01.2000, p. 539-544.

Research output: Contribution to journalArticle

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abstract = "We treated pregnant rats with 1 μg/kg body weight/day 1,2,3,4,6,7-hexachlorinated naphthalene (1,2,3,4,6,7-HxCN) on days 14-16 of gestation and examined the effects on the reproductive systems of their male offspring at various phases of sexual maturation. Sperm count in the cauda epididymidis did not change in 1,2,3,4,6,7-HxCN-treated rats on postnatal day 89, the age of sexual maturity, but the sperm count in the cauda epididymidis did increase to approximately 180{\%} of the control value on postnatal day 62. In addition, homogenization-resistant testicular spermatids increased to approximately 160{\%} of the control value on postnatal day 48, and the percent of postmeiotic tubules increased to approximately 190{\%} of the control value on postnatal day 31 in this group. These results indicate that the onset of spermatogenesis was accelerated in the 1,2,3,4,6,7-HxCN rats. Serum concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) had already reached the maximum level on postnatal day 31 in the 1,2,3,4,6,7-HxCN group, suggesting that the onset of LH and FSH secretions from the pituitary gland was also accelerated and that this endocrine disruption was the cause of early onset of spermatogenesis in this group. In the fat of 1,2,3,4,6,7-HxCN-treated dams, 5.75 ± 2.81 ppb 1,2,3,4,6,7-HxCN was detected when offspring were weaned. This concentration was 5-10 times higher than that found in human adipose tissue.",
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